The area postrema: a critical mediator of brain-body interactions.

IF 7.5 1区 生物学 Q1 CELL BIOLOGY
Daniëlle van de Lisdonk, Bo Li
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引用次数: 0

Abstract

The dorsal vagal complex contains three structures: the area postrema, the nucleus tractus solitarii, and the dorsal motor nucleus of the vagus. These structures are tightly linked, both anatomically and functionally, and have important yet distinct roles in not only conveying peripheral bodily signals to the rest of the brain but in the generation of behavioral and physiological responses. Reports on the new discoveries in these structures were highlights of the symposium. In this outlook, we focus on the roles of the area postrema in mediating brain-body interactions and its potential utility as a therapeutic target, especially in cancer cachexia.

脑后区:脑-体互动的关键中介。
迷走神经背侧复合体包含三个结构:后区、孤束核和迷走神经背侧运动核。这些结构在解剖学和功能上紧密相连,不仅在向大脑其他部分传递外周身体信号方面,而且在产生行为和生理反应方面发挥着重要而独特的作用。有关这些结构新发现的报告是本次研讨会的亮点。在本展望中,我们将重点关注后脑区在介导脑-体相互作用中的作用及其作为治疗靶点的潜在效用,尤其是在癌症恶病质中的作用。
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来源期刊
Genes & development
Genes & development 生物-发育生物学
CiteScore
17.50
自引率
1.90%
发文量
71
审稿时长
3-6 weeks
期刊介绍: Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).
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