An outbreak associated with Escherichia albertii in a junior high school, China.

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Epidemiology and Infection Pub Date : 2024-10-04 DOI:10.1017/S0950268824001341

Shiwang Huang, Qian Liu, Yezhen Fang, Hua Yu, Xi Yang, Jinfeng Hu, Yiyi Wang, Rui Tian, Yixiao Gao, Zhimin Ni, Yanwen Xiong

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Abstract

Escherichia albertii is an emerging foodborne enteropathogen associated with infectious diarrhoea in humans. In February 2023, an outbreak of acute gastroenteric cases was reported in a junior high school located in Hangzhou, Zhejiang province, China. Twenty-two investigated patients presented diarrhoea (22/22, 100%), abdominal pain (21/22, 95.5%), nausea (6/22, 27.3%), and vomiting (3/22, 13.6%). E. albertii strains were successfully isolated from anal swabs collected from six patients. Each isolate was classified as sequence type ST2686, harboured eae-β gene, and carried both cdtB-I and cdtB-II subtypes, being serotyped as EAOg32:EAHg4 serotype. A comprehensive whole-genome phylogenetic analysis revealed that the six isolates formed a distinct cluster, separate from other strains. These isolates exhibited minimal genetic variation, differing from one another by 0 to 1 single nucleotide polymorphism, suggesting a common origin from a single clone. To the best of our knowledge, this represented the first reported outbreak of gastroenteritis attributed to E. albertii outside of Japan on a global scale.

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中国一所初中爆发白细胞埃希氏菌疫情。

白细胞埃希氏菌是一种新出现的食源性肠道病原体，与人类感染性腹泻有关。2023 年 2 月，中国浙江省杭州市一所初中爆发了急性肠胃炎病例。22名接受调查的患者出现腹泻（22/22，100%）、腹痛（21/22，95.5%）、恶心（6/22，27.3%）和呕吐（3/22，13.6%）。从六名患者的肛拭子中成功分离出了白喉杆菌菌株。每个分离株都被归类为序列类型 ST2686，携带 eae-β 基因，同时携带 cdtB-I 和 cdtB-II 亚型，血清型为 EAOg32:EAHg4 血清型。一项全面的全基因组系统发育分析表明，这六个分离株形成了一个独特的集群，与其他菌株分开。这些分离株的遗传变异极小，彼此间只有 0 至 1 个单核苷酸多态性差异，这表明它们共同起源于一个克隆。据我们所知，这是在全球范围内首次报告日本以外地区爆发白喉杆菌引起的肠胃炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epidemiology and Infection 医学-传染病学

CiteScore

4.10

自引率

2.40%

发文量

366

审稿时长

3-6 weeks

期刊介绍： Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.