{"title":"Do ketone supplements regulate islet hormone secretion?","authors":"Jamie W Joseph","doi":"10.1210/endocr/bqae133","DOIUrl":null,"url":null,"abstract":"<p><p>Ketone supplementation has been gaining interest in improving health and treating some diseases, such as diabetes. However, the mechanism of action of how these ketone supplements work is not fully understood. In a recent paper, Banerjee et al. (2024) showed that physiological concentrations of βHB can affect hormone secretion and signalling within pancreatic islets. They showed that acute treatment with βHB increases insulin secretion and decreases glucagon secretion at physiological glucose concentrations. Their studies also suggest chronic βHB treatment may protect human islet cells from cytokine-induced cell death. Although more work is needed, it is possible that physiological concentrations of βHB may influence hormone secretion and signalling within islets.</p>","PeriodicalId":11819,"journal":{"name":"Endocrinology","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/endocr/bqae133","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Ketone supplementation has been gaining interest in improving health and treating some diseases, such as diabetes. However, the mechanism of action of how these ketone supplements work is not fully understood. In a recent paper, Banerjee et al. (2024) showed that physiological concentrations of βHB can affect hormone secretion and signalling within pancreatic islets. They showed that acute treatment with βHB increases insulin secretion and decreases glucagon secretion at physiological glucose concentrations. Their studies also suggest chronic βHB treatment may protect human islet cells from cytokine-induced cell death. Although more work is needed, it is possible that physiological concentrations of βHB may influence hormone secretion and signalling within islets.
期刊介绍：
The mission of Endocrinology is to be the authoritative source of emerging hormone science and to disseminate that new knowledge to scientists, clinicians, and the public in a way that will enable "hormone science to health." Endocrinology welcomes the submission of original research investigating endocrine systems and diseases at all levels of biological organization, incorporating molecular mechanistic studies, such as hormone-receptor interactions, in all areas of endocrinology, as well as cross-disciplinary and integrative studies. The editors of Endocrinology encourage the submission of research in emerging areas not traditionally recognized as endocrinology or metabolism in addition to the following traditionally recognized fields: Adrenal; Bone Health and Osteoporosis; Cardiovascular Endocrinology; Diabetes; Endocrine-Disrupting Chemicals; Endocrine Neoplasia and Cancer; Growth; Neuroendocrinology; Nuclear Receptors and Their Ligands; Obesity; Reproductive Endocrinology; Signaling Pathways; and Thyroid.
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