Altered Subcortical Brain Volume and Cortical Thickness Related to Insulin Resistance in Type 2 Diabetes Mellitus

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-04 DOI:10.1002/brb3.70055

Zidong Cao, Limin Ge, Weiye Lu, Kui Zhao, Yuna Chen, Zhizhong Sun, Wenbin Qiu, Xiaomei Yue, Yifan Li, Shijun Qiu

{"title":"Altered Subcortical Brain Volume and Cortical Thickness Related to Insulin Resistance in Type 2 Diabetes Mellitus","authors":"Zidong Cao, Limin Ge, Weiye Lu, Kui Zhao, Yuna Chen, Zhizhong Sun, Wenbin Qiu, Xiaomei Yue, Yifan Li, Shijun Qiu","doi":"10.1002/brb3.70055","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>The objective of this study is to examine the alterations in subcortical brain volume and cortical thickness among individuals diagnosed with Type 2 diabetes mellitus (T2DM) through the application of morphometry techniques and, additionally, to investigate the potential association between these modifications and insulin resistance (IR).</p>\n </section>\n \n <section>\n \n <h3> Materials and methods</h3>\n \n <p>The present cross-sectional study comprised a total of 121 participants (<i>n</i> = 48 with healthy controls [HCs] and <i>n</i> = 73 with T2DM) who were recruited and underwent a battery of cognitive testing and structural magnetic resonance imaging (MRI). FreeSurfer was used to process the MRI data. Analysis of covariance compared discrepancies in cortical thickness and subcortical brain volume between T2DM and HCs, adjusting for the potential confounding effects of gender, age, education, and body mass index (BMI). Exploratory partial correlations investigated links between IR and brain structure in T2DM participants.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Compared with HCs, individuals with T2DM demonstrated a cortical thickness decrease in the right caudal middle frontal gyrus, right pars opercularis, left precentral gyrus, and bilateral superior frontal gyrus. Furthermore, this study for T2DM found that the severity of IR was inversely related to the volume of the left putamen and left hippocampus, as well as the thickness of the left pars orbitalis, left pericalcarine, right entorhinal area, and right rostral anterior cingulate gyrus.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The evidence for structural brain changes in T2DM was observed, and alterations in cortical thickness were concentrated in the frontal lobes. Correlations between IR and frontal cortical thinning may serve as a potential neuroimaging marker of T2DM and lead to various diabetes-related brain complications.</p>\n </section>\n </div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450253/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/brb3.70055","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

The objective of this study is to examine the alterations in subcortical brain volume and cortical thickness among individuals diagnosed with Type 2 diabetes mellitus (T2DM) through the application of morphometry techniques and, additionally, to investigate the potential association between these modifications and insulin resistance (IR).

Materials and methods

The present cross-sectional study comprised a total of 121 participants (n = 48 with healthy controls [HCs] and n = 73 with T2DM) who were recruited and underwent a battery of cognitive testing and structural magnetic resonance imaging (MRI). FreeSurfer was used to process the MRI data. Analysis of covariance compared discrepancies in cortical thickness and subcortical brain volume between T2DM and HCs, adjusting for the potential confounding effects of gender, age, education, and body mass index (BMI). Exploratory partial correlations investigated links between IR and brain structure in T2DM participants.

Results

Compared with HCs, individuals with T2DM demonstrated a cortical thickness decrease in the right caudal middle frontal gyrus, right pars opercularis, left precentral gyrus, and bilateral superior frontal gyrus. Furthermore, this study for T2DM found that the severity of IR was inversely related to the volume of the left putamen and left hippocampus, as well as the thickness of the left pars orbitalis, left pericalcarine, right entorhinal area, and right rostral anterior cingulate gyrus.

Conclusion

The evidence for structural brain changes in T2DM was observed, and alterations in cortical thickness were concentrated in the frontal lobes. Correlations between IR and frontal cortical thinning may serve as a potential neuroimaging marker of T2DM and lead to various diabetes-related brain complications.

查看原文本刊更多论文

皮层下脑容量和皮层厚度的改变与 2 型糖尿病患者的胰岛素抵抗有关。

目的：本研究的目的是通过应用形态计量学技术研究确诊为2型糖尿病（T2DM）患者的皮层下脑容量和皮层厚度的变化，并探讨这些变化与胰岛素抵抗（IR）之间的潜在关联：本横断面研究共招募了 121 名参与者（健康对照组 48 人，T2DM 患者 73 人），他们接受了一系列认知测试和结构磁共振成像（MRI）检查。FreeSurfer用于处理核磁共振成像数据。协方差分析比较了 T2DM 和 HC 之间皮层厚度和皮层下脑容量的差异，并对性别、年龄、教育程度和体重指数 (BMI) 的潜在混杂影响进行了调整。探索性偏相关研究调查了T2DM参与者的IR与大脑结构之间的联系：结果：与普通人相比，T2DM 患者右侧额叶中回尾部、右侧厣旁、左侧中央前回和双侧额叶上回的皮质厚度减少。此外，这项针对 T2DM 的研究还发现，IR 的严重程度与左侧丘脑和左侧海马的体积以及左侧眶旁、左侧脐周、右侧内侧区和右侧喙扣带前回的厚度成反比：结论：有证据表明，T2DM患者的大脑结构发生了变化，皮质厚度的改变主要集中在额叶。红外和额叶皮质变薄之间的相关性可作为 T2DM 的潜在神经影像学标志，并导致各种与糖尿病相关的脑部并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464