Lung cancer and smoking: years lived with disability in Tuscany (Italy). An analysis from the ACAB study.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2024-10-03 DOI:10.1186/s12889-024-20109-4

Maria Chiara Malevolti, Michela Baccini, Adele Caldarella, Giorgio Garofalo, Giuseppe Gorini, Miriam Levi, Gianfranco Manneschi, Giovanna Masala, Lorenzo Monasta, Fancesco Profili, Giulia Carreras

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引用次数: 0

Abstract

Background: Lung cancer (LC) is among the most common neoplasms, mostly caused by smoking. This study, carried out within the ACAB project, aims to provide local, updated and systematic estimates of years lived with disability (YLD) from LC due to smoking in the Tuscany region, Italy.

Methods: We estimated YLD for the year 2022 for the whole region and at subregional level by local health unit (LHU) using data from the Tuscany Cancer Registry and local surveys. YLD were calculated by applying the severity-specific LC prevalence, estimated with an incidence-based disease model, to the corresponding disability weight. The burden from smoking was computed by: modelling the prevalence of smokers with a Bayesian Dirichlet-Multinomial regression model; estimating the distribution of smokers by pack-years simulating individual smoking histories; collecting relative risks from the literature.

Results: In 2022 in Tuscany, LC caused 7.79 (95% uncertainty interval [UI] = 2.26, 17.27) and 25.50 (95% UI = 7.30, 52.68) YLDs per 100,000 females and males, respectively, with slight variations by LHU, and 53% and 66% of the YLDs were caused by smoking.

Conclusion: The updated estimates of the burden of LC attributable to smoking for the Tuscany region as a whole and for each LHU provide indications to inform strategic prevention plans and set public health priorities. The impact of smoking on YLDs from LC is not negligible and heterogeneous by LHU, thus requiring local interventions.

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肺癌与吸烟：托斯卡纳（意大利）的残疾生活年数。ACAB 研究分析。

背景：肺癌（LC）是最常见的肿瘤之一，主要由吸烟引起。本研究是在 ACAB 项目范围内开展的，旨在对意大利托斯卡纳大区因吸烟导致肺癌的残疾生活年数（YLD）进行本地、最新和系统的估算：我们利用托斯卡纳癌症登记处和地方调查的数据，对 2022 年整个大区和地方卫生单位 (LHU) 的亚区水平的 YLD 进行了估算。计算 YLD 的方法是，将基于发病率的疾病模型估算出的严重程度特定的 LC 患病率与相应的残疾权重相加。吸烟造成的负担是通过以下方法计算得出的：利用贝叶斯迪里赫特-多项式回归模型对吸烟者的患病率进行建模；模拟个人吸烟史，按包年估算吸烟者的分布情况；收集文献中的相对风险：2022年，在托斯卡纳地区，每10万名女性和男性中分别有7.79例（95%不确定区间[UI] = 2.26例，17.27例）和25.50例（95%不确定区间[UI] = 7.30例，52.68例）慢性淋巴细胞白血病患者，LHU的情况略有不同，53%和66%的慢性淋巴细胞白血病患者是由吸烟引起的：托斯卡纳大区整体和各 LHU 因吸烟造成的低密度脂蛋白血症负担的最新估计值为制定战略性预防计划和公共卫生优先事项提供了参考。吸烟对因低血糖引起的青壮年死亡率的影响不容忽视，而且各 LHU 的情况也不尽相同，因此需要采取地方干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.