The Therapeutic Potential of Exosome Therapy in Sepsis Management: Addressing Complications and Improving Outcomes".

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Biophysics Pub Date : 2024-10-03 DOI:10.1007/s12013-024-01564-7

Payam Ali-Khiavi, Mahya Mohammadi, Sajjad Masoumi, Hossein Saffarfar, Reza Kheradmand, Ahmad Mobed, Faezeh Hatefnia

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引用次数: 0

Abstract

Infection occurs when pathogens penetrate tissues, reproduce, and trigger a host response to both the infectious agents and their toxins. A diverse array of pathogens, including viruses and bacteria, can cause infections. The host's immune system employs several mechanisms to combat these infections, typically involving an innate inflammatory response. Inflammation is a complex biological reaction that can affect various parts of the body and is a key component of the response to harmful stimuli. Sepsis arises when the body's response to infection leads to widespread damage to tissues and organs, potentially resulting in severe outcomes or death. The initial phase of sepsis involves immune system suppression. Early identification and targeted management are crucial for improving sepsis outcomes. Common treatment approaches include antibiotics, intravenous fluids, blood cultures, and monitoring urine output. This study explores the potential of exosome therapy in enhancing the management and alleviation of sepsis symptoms.

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外泌体疗法在败血症治疗中的治疗潜力：解决并发症和改善疗效"。

当病原体侵入组织、繁殖并引发宿主对感染病原体及其毒素的反应时，就会发生感染。包括病毒和细菌在内的各种病原体都可能引起感染。宿主的免疫系统采用多种机制来对抗这些感染，其中通常包括先天性炎症反应。炎症是一种复杂的生物反应，可影响身体的各个部位，是对有害刺激做出反应的关键组成部分。当人体对感染的反应导致组织和器官广泛受损，并可能导致严重后果或死亡时，就会引发败血症。败血症的初期阶段涉及免疫系统抑制。早期识别和针对性治疗对改善败血症预后至关重要。常见的治疗方法包括抗生素、静脉输液、血液培养和监测尿量。本研究探讨了外泌体疗法在加强管理和缓解败血症症状方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.