Genetic African ancestry modifies the biology of acute myeloid leukemia

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-10-04 DOI:10.1038/s41588-024-01869-6

Evelyn M. Jiagge

引用次数: 0

Abstract

African American patients were under-represented in the studies that led to the current patient classification system for acute myeloid leukemia (AML). A new in-depth analysis of the genetics of AML in African Americans suggests that this omission has implications for patient care.

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非洲裔遗传改变了急性髓性白血病的生物学特性

非裔美国人患者在研究中的代表性不足，而这些研究促成了目前的急性髓性白血病（AML）患者分类系统。一项关于非裔美国人急性髓性白血病遗传学的新的深入分析表明，这种遗漏对病人护理有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution