Early human development and stem cell-based human embryo models

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-10-03 DOI:10.1016/j.stem.2024.09.002

Marta N. Shahbazi, Vincent Pasque

引用次数: 0

Abstract

The use of stem cells to model the early human embryo promises to transform our understanding of developmental biology and human reproduction. In this review, we present our current knowledge of the first 2 weeks of human embryo development. We first focus on the distinct cell lineages of the embryo and the derivation of stem cell lines. We then discuss the intercellular crosstalk that guides early embryo development and how this crosstalk is recapitulated in vitro to generate stem cell-based embryo models. We highlight advances in this fast-developing field, discuss current limitations, and provide a vision for the future.

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人类早期发育和基于干细胞的人类胚胎模型

利用干细胞建立人类早期胚胎模型有望改变我们对发育生物学和人类生殖的认识。在这篇综述中，我们将介绍人类胚胎发育头两周的现有知识。我们首先关注胚胎的不同细胞系和干细胞系的衍生。然后，我们讨论了指导早期胚胎发育的细胞间串联，以及如何在体外重现这种串联以生成基于干细胞的胚胎模型。我们将重点介绍这一快速发展领域的进展，讨论当前的局限性，并展望未来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.