Let’s get functional: Drug sensitivity profiling to enable precision sarcoma medicine

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-10-03 DOI:10.1016/j.stem.2024.09.006

Claudia R. Ball, Stefan Fröhling

引用次数: 0

Abstract

Drug sensitivity profiling in patient-derived tumor models offers new hope for improving outcomes in cancers lacking effective therapies. Al Shihabi et al.¹ demonstrate that short-term cultures from bone and soft tissue sarcomas enable clinically meaningful screening of multiple drugs and combinations, marking a significant advance in personalized care for these high-risk diseases.

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让我们发挥功能：通过药物敏感性分析实现肉瘤精准医疗

患者衍生肿瘤模型的药物敏感性分析为改善缺乏有效疗法的癌症的治疗效果带来了新希望。Al Shihabi 等人1 证明，骨和软组织肉瘤的短期培养物能够对多种药物和组合进行有临床意义的筛选，标志着这些高风险疾病的个性化治疗取得了重大进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.