Cell-wide arrangement of Golgi/RE units depends on the microtubule organization.

IF 2 4区 生物学 Q4 CELL BIOLOGY
Cell structure and function Pub Date : 2024-11-07 Epub Date: 2024-10-03 DOI:10.1247/csf.24055
Tatsuya Tago, Syara Fujii, Shogo Sasaki, Maki Shirae-Kurabayashi, Naoaki Sakamoto, Takashi Yamamoto, Makoto Maeda, Tatsuya Ueki, Takunori Satoh, Akiko K Satoh
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引用次数: 0

Abstract

We have previously shown that Golgi stacks and recycling endosomes (REs) exist as Golgi/RE units in sea urchin embryos. In this study, we showed that Golgi/RE units were scattered throughout the cytoplasm at early developmental stages but gathered to form a "Golgi ring" surrounding the centric REs at the blastula stage. This change in the cell-wide arrangement of Golgi/RE units coincided with a dramatic change in microtubule organization from a randomly oriented cortical pattern to radial arrays under the apical plasma membrane. A single gigantic Golgi apparatus surrounding centric RE is clearly associated with the center of the radial microtubule arrays. Furthermore, we found that in some animal species belonging to different clades, Golgi stacks lack lateral connections but are likely centralized by microtubule motors. These results suggest that Golgi centralization depends on the organization of the microtubule array in addition to the lateral linking between Golgi stacks.Key words: Golgi stack, recycling endosome, Golgi-ribbon, microtubule, cilium, sea urchin, ascidian.

高尔基体/RE 单元在整个细胞内的排列取决于微管组织。
我们之前已经证明,在海胆胚胎中,高尔基体堆和循环内体(RE)以高尔基体/RE 单元的形式存在。在这项研究中,我们发现高尔基体/RE 单元在早期发育阶段散布在整个细胞质中,但到了囊胚期,它们聚集在一起形成了一个围绕中心 RE 的 "高尔基体环"。高尔基体/RE单元在整个细胞内排列的这种变化,与微管组织从随机定向的皮层模式到顶端质膜下的辐射阵列的巨大变化相吻合。围绕中心 RE 的单个巨大高尔基体明显与径向微管阵列的中心有关。此外,我们还发现,在一些属于不同支系的动物物种中,高尔基体堆缺乏横向联系,但很可能是由微管马达集中起来的。这些结果表明,高尔基体的集中化除了取决于高尔基体堆之间的横向联系外,还取决于微管阵列的组织。关键字高尔基体堆、循环内质体、高尔基带、微管、纤毛、海胆、腹水动物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell structure and function
Cell structure and function 生物-细胞生物学
CiteScore
2.50
自引率
0.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Cell Structure and Function is a fully peer-reviewed, fully Open Access journal. As the official English-language journal of the Japan Society for Cell Biology, it is published continuously online and biannually in print. Cell Structure and Function publishes important, original contributions in all areas of molecular and cell biology. The journal welcomes the submission of manuscripts on research areas such as the cell nucleus, chromosomes, and gene expression; the cytoskeleton and cell motility; cell adhesion and the extracellular matrix; cell growth, differentiation and death; signal transduction; the protein life cycle; membrane traffic; and organelles.
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