Berberine extends healthspan and delays neurodegenerative diseases in Caenorhabditis elegans through ROS-dependent PMK-1/SKN-1 activation

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-09-26 DOI:10.1016/j.archger.2024.105644

Yi Xiao , Li Zhang , Hanlin Zhou , Yingwen Cui , Keer Chen , Han Zhang , Qinyi Wu , Fang Liu

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引用次数: 0

Abstract

Oxidative stress, or the chronic generation of reactive oxygen species (ROS), is thought to contribute to the progression of aging and aging related diseases. However, low degree of ROS generation has repeatedly been shown to be associated with beneficial outcomes via activation of protective signaling pathways. Berberine, a natural alkaloid isolated from Rhizomacoptidis, has a long history of medicinal use in both Ayurvedic and traditional Chinese medicine, which possesses anti-cancer, anti-inflammatory and anti-neurodegenerative properties. In this study, we utilize Caenorhabditis elegans to examine the mechanisms by which berberine influences healthspan and neurodegenerative diseases. We find that 10 μM berberine significantly extends healthy lifespan in wild type C. elegans. We further show that berberine generates ROS, which is followed by activation of PMK-1/SKN-1 to extend healthspan. Intriguingly, berberine also delays neurodegenerative diseases such as Alzheimer's and polyglutamine diseases in a PMK-1/SKN-1dependent manner. Our work suggests that berberine may be a viable candidate for the prevention and treatment of aging and aging related diseases.

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小檗碱通过ROS依赖性PMK-1/SKN-1活化作用延长秀丽隐杆线虫的健康寿命并延缓其神经退行性疾病。

氧化应激或活性氧（ROS）的慢性生成被认为是导致衰老和与衰老相关疾病进展的原因。然而，通过激活保护性信号通路，低程度的 ROS 生成已多次被证明与有益的结果相关。小檗碱是从Rhizomacoptidis中分离出来的一种天然生物碱，在阿育吠陀医学和传统中医学中有着悠久的药用历史，具有抗癌、抗炎和抗神经退行性病变的特性。在本研究中，我们利用秀丽隐杆线虫研究了小檗碱影响健康寿命和神经退行性疾病的机制。我们发现，10 μM 小檗碱能显著延长野生型秀丽隐杆线虫的健康寿命。我们进一步发现，小檗碱会产生 ROS，继而激活 PMK-1/SKN-1，从而延长健康寿命。有趣的是，小檗碱还能以 PMK-1/SKN-1 依赖性方式延缓神经退行性疾病，如阿尔茨海默氏症和多聚谷氨酰胺疾病。我们的研究表明，小檗碱可能是预防和治疗衰老及衰老相关疾病的可行候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.