Intracranial arteriosclerosis is not associated with cerebral amyloid deposition.

IF 4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-10-01 DOI:10.1002/dad2.70005

Anna M Streiber, Julia Neitzel, Phuong Thuy Nguyen Ho, Meike W Vernooij, Daniel Bos

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引用次数: 0

Abstract

Background: Intracranial arteriosclerosis and cerebral amyloid beta (Aβ) are both involved in the etiology of Alzheimer's disease (AD) dementia, but the direct link between these two pathologies remains elusive.

Methods: In 633 participants (mean age 69 years, 51% women) from the population-based Rotterdam Study, we quantified cerebral Aβ accumulation on amyloid positron emission tomography (PET). We assessed calcification of the intracranial internal carotid (ICAC) and vertebrobasilar arteries (VBAC) as proxies of arteriosclerosis on non-enhanced computed tomography (CT). Using logistic and linear regression, we studied the relationship of presence, burden, and type of calcification with the presence and burden of Aβ.

Results: We found no associations of ICAC [odds ratio (OR): 0.85, 95% confidence interval (CI): 0.43, 1.72] or VBAC [OR: 0.59, CI: 0.26, 1.24] with cerebral Aβ. The results did not vary across ICAC subtypes.

Discussion: Intracranial arteriosclerosis was not associated with cerebral Aβ, underscoring their independence in the etiology of AD dementia.

Highlights: Comprehensive assessment of intracranial arteriosclerosis (e.g., including subtypes).Intracranial arteriosclerosis in different arteries and cerebral Aβ are not related.Arteriosclerosis and Aβ likely influence Alzheimer's disease dementia independently.

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颅内动脉硬化与脑淀粉样蛋白沉积无关。

背景：颅内动脉硬化和脑淀粉样蛋白β（Aβ）都与阿尔茨海默病（AD）痴呆症的病因有关，但这两种病症之间的直接联系仍然难以捉摸：我们对淀粉样蛋白正电子发射断层扫描（PET）显示的大脑 Aβ 累积情况进行了量化。我们通过非增强型计算机断层扫描（CT）评估了颅内颈内动脉（ICAC）和椎基底动脉（VBAC）的钙化情况，以此作为动脉硬化的替代指标。我们使用逻辑回归和线性回归研究了钙化的存在、负担和类型与 Aβ 的存在和负担之间的关系：结果：我们发现 ICAC [比值比 (OR)：0.85，95% 置信区间 (CI)：0.43，1.72] 或 VBAC [比值比：0.59，CI：0.26，1.24] 与脑 Aβ 无关。讨论：讨论：颅内动脉硬化与脑Aβ没有关联，强调了两者在AD痴呆病因中的独立性：全面评估颅内动脉硬化（如包括亚型）.不同动脉的颅内动脉硬化与脑Aβ无关.动脉硬化和Aβ可能对阿尔茨海默病痴呆症有独立影响.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.