The persistence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) after SARS-CoV-2 infection: A systematic review and meta-analysis

IF 14.3 1区医学 Q1 INFECTIOUS DISEASES

Journal of Infection Pub Date : 2024-09-29 DOI:10.1016/j.jinf.2024.106297

Ankush Dehlia, Mark A. Guthridge

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引用次数: 0

Abstract

Objectives

Long COVID-19 (LC) patients experience a number of chronic idiopathic symptoms that are highly similar to those of post-viral myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We have therefore performed a systematic review and meta-analysis to determine the proportion of LC patients that satisfy ME/CFS diagnostic criteria.

Methods

Clinical studies published between January 2020 and May 2023 were identified using the PubMed, Web of Science, Embase and CINAHL databases. Publication inclusion/exclusion criteria were formulated using the global CoCoPop framework. Data were pooled using a random-effects model with a restricted maximum-likelihood estimator. Study quality was assessed using the Joanna Briggs Institute critical assessment tool.

Results

We identified 13 eligible studies that reported a total of 1973 LC patients. Our meta-analysis indicated that 51% (95% CI, 42%−60%) of LC patients satisfied ME/CFS diagnostic criteria, with fatigue, sleep disruption, and muscle/joint pain being the most common symptoms. Importantly, LC patients also experienced the ME/CFS hallmark symptom, post-exertional malaise.

Conclusions

Our study not only demonstrates that LC patients exhibit similar symptom clusters to ME/CFS, but that approximately half of LC patients satisfy a diagnosis of ME/CFS. Our findings suggest that current ME/CFS criteria could be adapted to the identification of a subset of LC patients that may facilitate the standardised diagnosis, management and the recruitment for clinical studies in the future.

查看原文本刊更多论文

SARS-CoV-2感染后肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的持续存在：系统回顾和荟萃分析。

目的：长COVID-19（LC）患者会出现一些慢性特发性症状，这些症状与病毒后肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的症状极为相似。因此，我们进行了一项系统回顾和荟萃分析，以确定符合 ME/CFS 诊断标准的 LC 患者比例：方法：我们使用 PubMed、Web of Science、Embase 和 CINAHL 数据库对 2020 年 1 月至 2023 年 5 月间发表的临床研究进行了鉴定。采用全球 CoCoPop 框架制定了出版物纳入/排除标准。采用随机效应模型和限制性最大似然估计法对数据进行汇总。研究质量采用乔安娜-布里格斯研究所的关键评估工具进行评估：我们确定了 13 项符合条件的研究，共报告了 1,973 名 LC 患者。我们的荟萃分析表明，51%（95% CI，42%-60%）的 LC 患者符合 ME/CFS 诊断标准，疲劳、睡眠障碍和肌肉/关节疼痛是最常见的症状。重要的是，LC 患者还出现了 ME/CFS 的标志性症状--劳累后乏力：我们的研究不仅证明了 LC 患者表现出与 ME/CFS 相似的症状群，而且大约一半的 LC 患者符合 ME/CFS 的诊断标准。我们的研究结果表明，目前的ME/CFS标准可用于确定LC患者的子集，这将有助于标准化诊断、管理和未来临床研究的招募：数据可应要求提供。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.