Ultra-high resolution spectral photon-counting CT outperforms dual layer CT for lung imaging: Results of a phantom study.

IF 4.9 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Diagnostic and Interventional Imaging Pub Date : 2024-10-01 DOI:10.1016/j.diii.2024.09.011

Hugo Lacombe, Joey Labour, Fabien de Oliveira, Antoine Robert, Angèle Houmeau, Marjorie Villien, Sara Boccalini, Jean-Paul Beregi, Philippe C Douek, Joël Greffier, Salim A Si-Mohamed

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引用次数: 0

Abstract

Purpose: The purpose of this study was to compare lung image quality obtained with ultra-high resolution (UHR) spectral photon-counting CT (SPCCT) with that of dual-layer CT (DLCT), at standard and low dose levels using an image quality phantom and an anthropomorphic lung phantom.

Methods: An image quality phantom was scanned using a clinical SPCCT prototype and an 8 cm collimation DLCT from the same manufacturer at 10 mGy. Additional acquisitions at 6 mGy were performed with SPCCT only. Images were reconstructed with dedicated high-frequency reconstruction kernels, slice thickness between 0.58 and 0.67 mm, and matrix between 512² and 1024² mm, using a hybrid iterative algorithm at level 6. Noise power spectrum (NPS), task-based transfer function (TTF) for iodine and air inserts, and detectability index (d') were assessed for ground-glass and solid nodules of 2 mm to simulate highly detailed lung lesions. Subjective analysis of an anthropomorphic lung phantom was performed by two radiologists using a five-point quality score.

Results: At 10 mGy, noise magnitude was reduced by 29.1 % with SPCCT images compared to DLCT images for all parameters (27.1 ± 11.0 [standard deviation (SD)] HU vs. 38.2 ± 1.0 [SD] HU, respectively). At 6 mGy with SPCCT images, noise magnitude was reduced by 8.9 % compared to DLCT images at 10 mGy (34.8 ± 14.1 [SD] HU vs. 38.2 ± 1.0 [SD] HU, respectively). At 10 mGy and 6 mGy, average NPS spatial frequency (f_av) was greater for SPCCT images (0.75 ± 0.17 [SD] mm^-1) compared to DLCT images at 10 mGy (0.55 ± 0.04 [SD] mm^-1) while remaining constant from 10 to 6 mGy. At 10 mGy, TTF at 50 % (f₅₀) was greater for SPCCT images (0.92 ± 0.08 [SD] mm^-1) compared to DLCT images (0.67 ± 0.06 [SD] mm^-1) for both inserts. At 6 mGy, f₅₀ decreased by 1.1 % for SPCCT images, while remaining greater compared to DLCT images at 10 mGy (0.91 ± 0.06 [SD] mm^-1 vs. 0.67 ± 0.06 [SD] mm^-1, respectively). At both dose levels, d' were greater for SPCCT images compared to DLCT for all clinical tasks. Subjective analysis performed by two radiologists revealed a greater median image quality for SPCCT (5; Q1, 4; Q3, 5) compared to DLCT images (3; Q1, 3; Q3, 3).

Conclusion: UHR SPCCT outperforms DLCT in terms of image quality for lung imaging. In addition, UHR SPCCT contributes to a 40 % reduction in radiation dose compared to DLCT.

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超高分辨率光谱光子计数 CT 在肺部成像方面优于双层 CT：模型研究结果

目的：本研究的目的是使用图像质量模型和拟人肺部模型，比较超高分辨率（UHR）光谱光子计数 CT（SPCCT）和双层 CT（DLCT）在标准和低剂量水平下获得的肺部图像质量：方法：使用临床 SPCCT 原型和同一制造商生产的 8 厘米准直 DLCT，在 10 mGy 下扫描图像质量模型。仅使用 SPCCT 进行了 6 mGy 的额外采集。图像采用专用的高频重建内核进行重建，切片厚度在 0.58 至 0.67 毫米之间，矩阵在 5122 至 10242 毫米之间，使用 6 级混合迭代算法。对 2 毫米的磨玻璃结节和实性结节的噪声功率谱（NPS）、碘和空气插入的任务转移函数（TTF）以及可探测性指数（d'）进行了评估，以模拟高度精细的肺部病变。两名放射科医生采用五点质量评分法对拟人肺部模型进行了主观分析：10 mGy时，与DLCT图像相比，SPCCT图像在所有参数上的噪声幅度降低了29.1%（分别为27.1 ± 11.0 [SD] HU vs. 38.2 ± 1.0 [SD] HU）。在 6 mGy 时，与 10 mGy 时的 DLCT 图像相比，SPCCT 图像的噪声幅度降低了 8.9%（分别为 34.8 ± 14.1 [SD] HU 与 38.2 ± 1.0 [SD] HU）。在 10 mGy 和 6 mGy 时，SPCCT 图像的平均 NPS 空间频率（fav）（0.75 ± 0.17 [SD] mm-1）高于 10 mGy 时的 DLCT 图像（0.55 ± 0.04 [SD] mm-1），但在 10 至 6 mGy 期间保持不变。10 mGy时，SPCCT图像的50% TTF（f50）大于DLCT图像（0.67 ± 0.06 [SD] mm-1）。在 6 mGy 时，SPCCT 图像的 f50 下降了 1.1%，而在 10 mGy 时仍大于 DLCT 图像（分别为 0.91 ± 0.06 [SD] mm-1 vs. 0.67 ± 0.06 [SD] mm-1）。在两种剂量水平下，在所有临床任务中，SPCCT 图像的 d' 均大于 DLCT。由两名放射科医生进行的主观分析显示，与DLCT图像（3；Q1，3；Q3，3）相比，SPCCT图像质量的中位数更高（5；Q1，4；Q3，5）：结论：UHR SPCCT 的肺部成像质量优于 DLCT。结论：就肺部成像质量而言，UHR SPCCT 优于 DLCT。此外，与 DLCT 相比，UHR SPCCT 可使辐射剂量减少 40%。

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来源期刊

Diagnostic and Interventional Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

8.50

自引率

29.10%

发文量

126

审稿时长

11 days

期刊介绍： Diagnostic and Interventional Imaging accepts publications originating from any part of the world based only on their scientific merit. The Journal focuses on illustrated articles with great iconographic topics and aims at aiding sharpening clinical decision-making skills as well as following high research topics. All articles are published in English. Diagnostic and Interventional Imaging publishes editorials, technical notes, letters, original and review articles on abdominal, breast, cancer, cardiac, emergency, forensic medicine, head and neck, musculoskeletal, gastrointestinal, genitourinary, interventional, obstetric, pediatric, thoracic and vascular imaging, neuroradiology, nuclear medicine, as well as contrast material, computer developments, health policies and practice, and medical physics relevant to imaging.