The role of reproductive tract extracellular vesicles on boar sperm function

IF 2.4 2区农林科学 Q3 REPRODUCTIVE BIOLOGY

Theriogenology Pub Date : 2024-09-27 DOI:10.1016/j.theriogenology.2024.09.029

Zhiqian Xu , Ke Zhang , Youbing Yang, Huixian Chang, Fengyun Wen, Xiaoxia Li

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are abundant in reproductive tract fluids and serve as important mediators of paracrine communication, influencing the function of gametes. Sperm undergo development in the male reproductive tract and exert their function within the female reproductive tract, engaging in interactions with various types of EVs present throughout the reproductive system. Previous studies have demonstrated that both male and female reproductive tract EVs can impact sperm function by transferring regulatory cargoes to them. Nevertheless, inconsistencies of previous research regarding the effects of EVs on sperm function, coupled with a lack of investigation into the influence of female reproductive tract EVs on sperm fertilization, have left the true role and underlying mechanisms of reproductive tract EVs on sperm function largely unexplored. Given that pigs represent significant economic livestock and serve as an ideal biomedical model for human diseases, this review aims to provide a comprehensive summary of the current knowledge regarding reproductive tract EVs and their influence on boar sperm function, while highlighting their potential roles. We anticipate that this review will facilitate future research on reproductive tract EVs and their impact on sperm function, contributing to improved animal reproductive efficiency and advancements in the treatment of male infertility.

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生殖道细胞外囊泡对公猪精子功能的作用

细胞外囊泡（EVs）在生殖道液体中含量丰富，是旁分泌通讯的重要媒介，影响配子的功能。精子在男性生殖道中发育，在女性生殖道中发挥功能，与整个生殖系统中存在的各种类型的EV相互作用。以往的研究表明，男性和女性生殖道的EVs都能通过向精子转移调控货物来影响精子的功能。然而，以往关于 EVs 对精子功能影响的研究并不一致，再加上缺乏对雌性生殖道 EVs 对精子受精影响的研究，因此生殖道 EVs 对精子功能的真正作用和内在机制在很大程度上尚未被探索。鉴于猪是重要的经济牲畜，也是人类疾病的理想生物医学模型，本综述旨在全面总结目前有关生殖道 EVs 及其对公猪精子功能影响的知识，同时强调它们的潜在作用。我们希望这篇综述能促进今后有关生殖道 EVs 及其对精子功能影响的研究，从而提高动物的繁殖效率，推动男性不育症的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Theriogenology 农林科学-生殖生物学

CiteScore

5.50

自引率

14.30%

发文量

387

审稿时长

72 days

期刊介绍： Theriogenology provides an international forum for researchers, clinicians, and industry professionals in animal reproductive biology. This acclaimed journal publishes articles on a wide range of topics in reproductive and developmental biology, of domestic mammal, avian, and aquatic species as well as wild species which are the object of veterinary care in research or conservation programs.