Investigating the Relationship of G-137C, C-607A, and A-1447G Polymorphisms in the Promoter of IL-18 and CXCL10 Inflammatory Genes with Prostate Cancer in an Iranian Population.

IF 2.3 Q3 ONCOLOGY

Prostate Cancer Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.1155/2024/3997576

Nahid Ahmadi, Seyyed Amir Yasin Ahmadi, Abdolreza Kheirollahi, Farhad Shahsavar

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引用次数: 0

Abstract

Introduction: Genetic and environmental factors are involved in prostate cancer. The current study was conducted to study the relationship between G-137C, C-607A, and A-1447G polymorphisms in the promoter of IL-18 and CXCL10 inflammatory genes with prostate cancer.

Methods: As a genetic association study with a case-control design, the genomes of people living in Khorasan, Iran, were compared in two groups of cases and controls. The genotype of the A-1447G polymorphism present in the CXCL10 gene promoter was investigated by the PCR-RFLP method. PCR-SSP was used to study the genotype of G-137C and C-607A polymorphisms present in the IL-18 gene promoter. Odds ratio (OR) and 95% confidence interval (CI) were reported.

Results: One mutant allele in CXCL10 A-1447G polymorphism (AG) increased the chance of cancer (OR = 4.902, 95% CI = 2.70-8.87) and two mutant alleles (GG) increased more (OR = 7.174, 95% CI = 2.48-20.68). One mutant allele in IL-18 G-137C polymorphism (CG) increased the chance of cancer (OR = 5.583, 95% CI = 3.04-10.22) and two mutant alleles (CC) increased more (OR = 9.571, 95% CI = 3.10-29.46). One mutant allele in IL-18 C607A polymorphism (CA) increased the chance of cancer (OR = 5.359, 95% CI = 2.95-9.70) and two mutant alleles (AA) increased more (OR = 7.083, 95% CI = 2.61-19.15) (P < 0.001).

Conclusion: According to the results, the mutant alleles in polymorphisms CXCL10 A-1447G, IL-18 G-137C, and IL-18 C-607A alleles were associated with an increased chance of prostate cancer in this population.

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研究伊朗人群中 IL-18 和 CXCL10 炎症基因启动子中 G-137C、C-607A 和 A-1447G 多态性与前列腺癌的关系。

简介前列腺癌与遗传和环境因素有关。本研究旨在探讨 IL-18 和 CXCL10 炎症基因启动子中的 G-137C、C-607A 和 A-1447G 多态性与前列腺癌的关系：作为一项采用病例对照设计的遗传关联研究，我们将伊朗呼罗珊地区居民的基因组分为病例组和对照组两组进行比较。采用 PCR-RFLP 方法调查了 CXCL10 基因启动子中 A-1447G 多态性的基因型。PCR-SSP用于研究IL-18基因启动子中G-137C和C-607A多态性的基因型。结果显示，CXL-18基因中有一个突变等位基因：结果：CXCL10 A-1447G多态性中的一个突变等位基因（AG）会增加患癌症的几率（OR = 4.902，95% CI = 2.70-8.87），而两个突变等位基因（GG）会增加患癌症的几率（OR = 7.174，95% CI = 2.48-20.68）。IL-18 G-137C 多态性中的一个突变等位基因（CG）会增加患癌症的几率（OR = 5.583，95% CI = 3.04-10.22），而两个突变等位基因（CC）会增加患癌症的几率（OR = 9.571，95% CI = 3.10-29.46）。IL-18 C607A多态性中的一个突变等位基因（CA）会增加患癌几率（OR = 5.359，95% CI = 2.95-9.70），而两个突变等位基因（AA）会增加患癌几率（OR = 7.083，95% CI = 2.61-19.15）（P < 0.001）：结果显示，在该人群中，CXCL10 A-1447G、IL-18 G-137C和IL-18 C-607A等位基因的突变等位基因与前列腺癌发病几率增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostate Cancer ONCOLOGY-

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.