Novel antifungal talaroenamine L with unusual leptosphaeronyl moiety from marine-derived Talaromyces sp. HDN17-428 via HDACi elicitation.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-10-01 DOI:10.1080/14786419.2024.2407503

Komal Anjum, Luning Zhou, Khizar Hayyat, Xiaofei Huang, Jiaxiang Wang, Guojian Zhang, Tianjiao Zhu, Qian Che, Dehai Li

引用次数: 0

Abstract

Vorinostat elicitation of the deep-sea fungus Talaromyces sp. HDN17-428 resulted in the isolation of one new compound, talaroenamine L (1) with unusual leptosphaeronyl moiety and three known compounds (2-4). Structures of 1-4 were confirmed by extensive NMR, HRESIMS and OR calculations. Antimicrobial activities of all compounds were tested in which compounds 1-4 showed substantial antifungal activities with MIC values ranged from 3.1 to 12.5 μM.

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通过 HDACi 诱导，从海洋来源的塔拉酵母菌 HDN17-428 中提取出具有不寻常钩端基的新型抗真菌塔拉烯胺 L。

通过对深海真菌 Talaromyces sp. HDN17-428 进行伏立诺司特诱导，分离出了一种新化合物 Talaroenamine L（1）和三种已知化合物（2-4）。通过大量核磁共振、HRESIMS 和 OR 计算，确认了 1-4 的结构。对所有化合物的抗菌活性进行了测试，其中 1-4 号化合物显示出很强的抗真菌活性，其 MIC 值介于 3.1 到 12.5 μM 之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.