A new isocoumarin from sponge endophytic fungus Aspergillus ochraceopetaliformis with cytotoxic activity.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-10-03 DOI:10.1080/14786419.2024.2411373

Ruitong Zhong, Chuanling Shi, Xiaoyun Wu, Yiting Zou, Jun Li, Yongqian Liang

引用次数: 0

Abstract

A new isocoumarin, 8-hydroxy-3-methyliscoumarin-6-yl acetate (1), was isolated together with five known compounds from sponge endophytic fungus Aspergillus ochraceopetaliformis. The structure of the new compound was established based on 1D and 2D NMR spectral analysis. Compounds 1-6 were evaluated for their cytotoxic activities and antimicrobial activities. Compounds 1 and 6 display cytotoxic activities against mouse melanoma cells B16 with IC₅₀ values 72.5 ± 2.6 and 1.0 ± 0.5 µM, respectively. Compounds 4 and 5 displayed faint antimicrobial activities of Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus.

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一种来自海绵内生真菌赭色曲霉的具有细胞毒性活性的新异香豆素。

从海绵内生真菌赭色曲霉（Aspergillus ochraceopetaliformis）中分离出了一种新的异香豆素--8-羟基-3-甲基香豆素-6-基乙酸酯（1），以及五种已知化合物。根据一维和二维核磁共振光谱分析，确定了新化合物的结构。对化合物 1-6 的细胞毒性活性和抗菌活性进行了评估。化合物 1 和 6 对小鼠黑色素瘤细胞 B16 具有细胞毒性活性，IC50 值分别为 72.5 ± 2.6 和 1.0 ± 0.5 µM。化合物 4 和 5 对枯草芽孢杆菌、黄体微球菌和金黄色葡萄球菌具有微弱的抗菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.