Association between cardiometabolic Index (CMI) and endometriosis: a cross-sectional study on NHANES.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2024-10-02 DOI:10.1186/s12944-024-02314-7

Jiameng Wang, Boyu Wang, Ting Liu, Jingying Shang, Xumeng Gu, Tianchan Zhang, Huifang Cong

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引用次数: 0

Abstract

Background: Endometriosis is intricately linked to metabolic health. The Cardiometabolic Index (CMI), a novel and readily accessible indicator, is utilized to evaluate metabolic status. This study seeks to investigate the potential correlation between CMI and endometriosis.

Methods: Data from four consecutive survey cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2006 were utilized. This included adult females with self-reported diagnoses of endometriosis and complete information required for calculating the CMI. The calculation formula for CMI is Triglycerides(TG) / High-density lipoprotein cholesterol (HDL-C) × WHtR (WHtR = waist circumference / height). A multivariable logistic regression model was employed to investigate the linear association between CMI and endometriosis. Subgroup analyses were performed to explore potential influencing factors. Additionally, the linear relationship was validated using restricted cubic spline (RCS) curve plotting and threshold effect analysis.

Results: This study, based on the National Health and Nutrition Examination Survey (NHANES), included a cohort of 2,224 adult women. The multivariable logistic regression analysis demonstrated that in the fully adjusted model, individuals with the highest CMI exhibited a 78% elevated likelihood of endometriosis compared to those with the lowest CMI (OR = 1.78; 95% CI, 1.02-3.11, P < 0.05). The subgroup analysis indicated that there were no significant interactions between CMI and specific subgroups (all interaction P > 0.05), except for the subgroup stratified by stroke status (P < 0.05). Additionally, the association between CMI and endometriosis was linear, with a 20% increase in the association for each unit increase in CMI when CMI > 0.67 (OR = 1.20; 95% CI, 1.05-1.37, P < 0.01).

Conclusion: The study found that CMI levels are closely correlated with endometriosis, with this correlation increasing when the CMI exceeds 0.67. This finding implies that by regularly monitoring CMI levels, physicians may be able to screen women at risk for endometriosis at an earlier stage, thereby enabling the implementation of early interventions to slow the progression of the disease. To further validate these findings, larger-scale cohort studies are required to support the results of this research.

查看原文本刊更多论文

心脏代谢指数（CMI）与子宫内膜异位症之间的关系：一项关于国家健康调查（NHANES）的横断面研究。

背景：子宫内膜异位症与代谢健康密切相关：子宫内膜异位症与代谢健康密切相关。心脏代谢指数（CMI）是一项新颖且易于获得的指标，可用于评估代谢状况。本研究旨在调查 CMI 与子宫内膜异位症之间的潜在相关性：研究采用了 1999 年至 2006 年间连续四个调查周期的美国国家健康与营养调查（NHANES）数据。这些数据包括自我报告诊断为子宫内膜异位症的成年女性，以及计算 CMI 所需的完整信息。CMI 的计算公式为甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）×WHtR（WHtR = 腰围/身高）。采用多变量逻辑回归模型研究 CMI 与子宫内膜异位症之间的线性关系。为了探究潜在的影响因素，还进行了分组分析。此外，还利用限制性立方样条曲线（RCS）绘制和阈值效应分析对线性关系进行了验证：本研究以美国国家健康与营养调查（NHANES）为基础，纳入了 2,224 名成年女性。多变量逻辑回归分析表明，在完全调整模型中，与 CMI 值最低的人相比，CMI 值最高的人患子宫内膜异位症的可能性要高出 78%（OR = 1.78；95% CI，1.02-3.11，P 0.05），但按中风状况分层的亚组除外（P 0.67（OR = 1.20；95% CI，1.05-1.37，P 结论：该研究发现，CMI 值与子宫内膜异位症的发病率密切相关：研究发现，CMI 水平与子宫内膜异位症密切相关，当 CMI 超过 0.67 时，相关性会增加。这一发现意味着，通过定期监测 CMI 水平，医生可以及早筛查出子宫内膜异位症的高危妇女，从而及早采取干预措施，延缓病情发展。为了进一步验证这些发现，需要进行更大规模的队列研究来支持这项研究成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.