Hand eczema and changes in the skin microbiome after 2 weeks of topical corticosteroid treatment.

IF 8.4 2区医学 Q1 DERMATOLOGY

Journal of the European Academy of Dermatology and Venereology Pub Date : 2024-10-03 DOI:10.1111/jdv.20366

Line Brok Nørreslet, Anna Cäcilia Ingham, Tove Agner, Caroline Meyer Olesen, Anne Bregnhøj, Mette Sommerlund, Paal Skytt Andersen, Marc Stegger, Charlotte Gotthard Mørtz, Sofie Marie Edslev

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Abstract

Background: More than 50% of patients with hand eczema (HE) are colonized with Staphylococcus aureus. Comprehensive knowledge of the skin microbiome and its changes in patients with HE may provide insights into future potential therapeutical targets.

Objective: To describe the skin microbiome in patients with moderate-to-severe chronic HE and assess its changes following treatment with topical corticosteroids (TCS).

Methods: Bacterial samples were collected from lesional and nonlesional skin before and after 2 weeks of TCS treatment using ESwabs and analysed by 16S rRNA and tuf gene sequencing. Clinically, the disease severity was assessed by the Hand Eczema Severity Index (HECSI).

Results: A cohort of 31 patients with HE were included and followed up. Compared to nonlesional skin, lesional skin differed in overall bacterial community composition (p = 0.02), displayed higher relative abundance of Staphylococcus, in particular S. aureus (p = 0.01) and lower abundance of Micrococcus (p = 0.02). As disease severity improved with treatment, these microbial characteristics on lesional skin shifted towards that of nonlesional skin on the hands.

Conclusion: The bacterial skin microbiome was altered in lesions of HE and partly driven by S. aureus colonization, however, shifted towards nonlesional skin following treatment. Our results emphasize the future possibilities for anti-S. aureus treatment strategies.

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手部湿疹和局部皮质类固醇治疗两周后皮肤微生物群的变化。

背景：50%以上的手部湿疹（HE）患者体内存在金黄色葡萄球菌。全面了解手部湿疹患者的皮肤微生物组及其变化可为未来潜在的治疗目标提供洞察力：描述中度至重度慢性 HE 患者的皮肤微生物组，并评估其在接受局部皮质类固醇激素（TCS）治疗后的变化：方法：使用 ESwabs 在 TCS 治疗 2 周前和 2 周后从皮损和非皮损皮肤收集细菌样本，并通过 16S rRNA 和 tuf 基因测序进行分析。临床上，通过手部湿疹严重程度指数（HECSI）评估疾病的严重程度：结果：纳入并随访了31名手部湿疹患者。与非皮损皮肤相比，皮损皮肤的细菌群落组成总体上有所不同（p = 0.02），葡萄球菌尤其是金黄色葡萄球菌的相对丰度较高（p = 0.01），而微球菌的丰度较低（p = 0.02）。随着治疗后疾病严重程度的改善，这些病变皮肤上的微生物特征向手部非病变皮肤上的微生物特征转变：结论：HE 病变皮肤的细菌微生物组发生了改变，部分原因是金黄色葡萄球菌定植，但在治疗后向非皮损皮肤转移。我们的研究结果强调了未来抗金葡菌治疗策略的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the European Academy of Dermatology and Venereology 医学-皮肤病学

CiteScore

10.70

自引率

8.70%

发文量

874

审稿时长

3-6 weeks

期刊介绍： The Journal of the European Academy of Dermatology and Venereology (JEADV) is a publication that focuses on dermatology and venereology. It covers various topics within these fields, including both clinical and basic science subjects. The journal publishes articles in different formats, such as editorials, review articles, practice articles, original papers, short reports, letters to the editor, features, and announcements from the European Academy of Dermatology and Venereology (EADV). The journal covers a wide range of keywords, including allergy, cancer, clinical medicine, cytokines, dermatology, drug reactions, hair disease, laser therapy, nail disease, oncology, skin cancer, skin disease, therapeutics, tumors, virus infections, and venereology. The JEADV is indexed and abstracted by various databases and resources, including Abstracts on Hygiene & Communicable Diseases, Academic Search, AgBiotech News & Information, Botanical Pesticides, CAB Abstracts®, Embase, Global Health, InfoTrac, Ingenta Select, MEDLINE/PubMed, Science Citation Index Expanded, and others.