Phytochemical analysis and in vitro biological activity assessment of extracts from Micromeria myrtifolia.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-10-03 DOI:10.1080/09603123.2024.2409829

Taskın T, Oksuz M, Rayaman E, Ermanoglu M, Taskın D, Acar A G, Kılıç Ö, Çalışkan Salihi E, Yılmaz Nur B, Elçioğlu Hk

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引用次数: 0

Abstract

In this study, the antioxidant capacity, the effect on anti-acetylcholinesterase and anti-urease enzyme inhibition, and kidney stone-reducing effects of different extracts from M.myrtifolia. In addition, the phytochemical content of the bioactive methanol extract was analyzed by HPLC-DAD. The methanol extract showed strong DPPH (IC₅₀:0.036 mg/mL) radical scavenging, Cu (II) ion (6.535 mmTroloxE) and Fe³⁺ (6.476 FeSO₄) ion reducing antioxidant activity compared to other extracts. The methanol extract contained the highest amount of phenolic (400 mgGAE) and flavonoid (2.519 QuE) compounds. Moreover, the methanol extract had significant anticholinesterase (78.935%), anti-urease (71.014%) and calcium oxalate anti-crystallization (18.22%, 37.427%) activities. The findings show that all extracts exhibited varying amounts of antibacterial activity against Staphylococcus aureus. The bioactive methanol extract contained rosmarinic acid (31.35 µg), quercetin (12.99 µg) and chlorogenic acid (3.55 µg). The analyzed compounds are thought to contribute significantly to the pharmacological effect of the methanol extract.

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小叶紫檀提取物的植物化学分析和体外生物活性评估

本研究对M.myrtifolia不同提取物的抗氧化能力、抗乙酰胆碱酯酶和抗尿酸酶抑制作用以及肾结石还原作用进行了研究。此外，还采用 HPLC-DAD 分析了具有生物活性的甲醇提取物的植物化学成分含量。与其他提取物相比，甲醇提取物具有很强的清除 DPPH（IC50:0.036 mg/mL）自由基、Cu (II) 离子（6.535 mmTroloxE）和 Fe3+ （6.476 FeSO4）离子还原的抗氧化活性。甲醇提取物中的酚类化合物（400 mgGAE）和黄酮类化合物（2.519 QuE）含量最高。此外，甲醇提取物还具有显著的抗胆碱酯酶（78.935%）、抗尿酸盐酶（71.014%）和草酸钙抗结晶（18.22%、37.427%）活性。研究结果表明，所有提取物都对金黄色葡萄球菌具有不同程度的抗菌活性。具有生物活性的甲醇提取物中含有迷迭香酸（31.35 µg）、槲皮素（12.99 µg）和绿原酸（3.55 µg）。所分析的化合物被认为对甲醇提取物的药理作用有重大贡献。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.