Computer aided villi morphometric quantification in video-capsule enteroscopy: A newly developed software to quantify small bowel atrophy.

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease Pub Date : 2024-10-01 DOI:10.1016/j.dld.2024.09.008

Nicoletta Nandi, Matilde Topa, Alessandro Rimondi, Michele M Ciulla, Gian Eugenio Tontini, Lucia Scaramella, Reena Sidhu, Maurizio Vecchi, Luca Elli

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引用次数: 0

Abstract

Background and aims: Small bowel capsule endoscopy (SBCE) has an established role in patients with non-responsive celiac disease (CeD). A non-invasive method to quantify small bowel atrophy is still lacking.

Methods: We analysed SBCE frames from CeD patients from 2018 to 2020. Histology was the reference standard, with atrophy defined as Marsh-Oberhuber score ≥ 3a. Three regions of interest (ROI) were blindly selected from each frame by an expert gastroenterologist and analysed using a National Institute of Health J image-processing software into a numerical scale. A 3D surface plot macro identified intestinal villi density through isolines plots.

Results: We acquired 306 ROIs from 57 frames with macroscopic atrophy and 45 with normal mucosa. Frames were classified as atrophic (n = 63) or non-atrophic (n = 39) per Marsh-Oberhuber classification. Median density score significantly differed between atrophic and non-atrophic frames (p < 0.001). The morphometric analysis showed a sensitivity of 77 % and a specificity of 79 % in discriminating between atrophic or non-atrophic mucosa with a 14.10 cut-off (Youden Index) and an overall AUC of 0.805 (CI 95 % 0.712-0.897).

Conclusions: Our newly developed SBCE software can effectively quantify villous atrophy. Further studies are needed to validate its applicability in an external cohort.

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视频胶囊肠镜中的计算机辅助绒毛形态定量：新开发的量化小肠萎缩的软件。

背景和目的：小肠胶囊内镜（SBCE）在无反应性乳糜泻（CeD）患者中的作用已经确立。目前仍缺乏量化小肠萎缩的无创方法：我们分析了2018年至2020年CeD患者的SBCE框架。组织学是参考标准，萎缩定义为 Marsh-Oberhuber 评分≥ 3a。胃肠病专家从每帧图像中盲选三个感兴趣区（ROI），并使用美国国家卫生研究院 J 图像处理软件进行数值化分析。三维表面图宏通过隔离图确定肠绒毛密度：我们从 57 个大面积萎缩和 45 个粘膜正常的病例中获取了 306 个 ROI。根据马什-奥伯胡伯分类法，病例被分为萎缩型（63 例）和非萎缩型（39 例）。中位密度评分在萎缩和非萎缩框架之间存在明显差异（p < 0.001）。形态计量分析表明，以 14.10 为临界值（尤登指数）区分萎缩和非萎缩粘膜的灵敏度为 77%，特异度为 79%，总体 AUC 为 0.805（CI 95 % 0.712-0.897）：我们新开发的 SBCE 软件能有效量化绒毛萎缩。结论：我们新开发的 SBCE 软件可有效量化绒毛萎缩，但还需进一步研究，以验证其在外部队列中的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.