Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI:10.22088/cjim.15.4.579

Maryam Sheikhi, Payam Siyadat, Mehrdad Rostami, Mohammad Hadi Sadeghian, Elnaz Zahiri, Mohammad Ghorbani, Hossein Ayatollahi, Amirali Ayatollahi, Reza Hemmatan Attarbashi, Zahra Khoshnegah

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Abstract

Background: NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. Despite substantial research illuminating the roles of NUP98 fusions in the course of AML, their impacts on the outcome of patients with AML should be explored in more detail. As a result, this meta-analysis was designed to provide further light on the prognostic implications of NUP98 fusions in AML.

Methods: We completed an extensive search in PubMed, Scopus, and Web of Science to identify papers evaluating the prognostic effects of NUP98 rearrangements in patients with AML until August 22, 2022. In total, 15 publications with 6142 participants fulfilled the requirements for the current meta-analysis. All the qualified studies were examined for information regarding HRs and 95% confidence interval (95%CI) for overall survival (OS) and event-free survival (EFS). In addition, we utilized Comprehensive Meta-analysis software version 2 (CMA2) for calculating pooled HRs and 95% CI.

Section title: Our Results : analyses for NUP98-NSD1 indicated that this fusion could significantly impact the outcome of patients with AML (pooled HR: 2.84; 95% CI: 2.49-3.24, P=0.000). Additionally, we observed a strong correlation between NUP98-KDM5A rearrangement and poor prognosis in AML (pooled HR: 2.65; 95% CI: 2.5-2.81; P=0.000). A subgroup analysis also showed that the NUP98-NSD1 and FLT3-ITD together confer a poor prognostic effect (pooled HR: 2.60, 95% CI: 1.61-4.18; P=0.000).

Conclusions: NUP98 fusions could significantly impact the outcome of patients with AML. The use of these fusions as prognostic indicators in AML seems rational.

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急性髓性白血病 NUP98 重排的预后重要性：系统回顾和荟萃分析。

背景：急性髓性白血病（AML）中的 NUP98 基因融合最近引起了广泛关注。尽管大量研究阐明了 NUP98 基因融合在急性髓性白血病病程中的作用，但它们对急性髓性白血病患者预后的影响仍有待更详细的探讨。因此，本荟萃分析旨在进一步揭示 NUP98 融合对急性髓细胞性白血病预后的影响：截至 2022 年 8 月 22 日，我们在 PubMed、Scopus 和 Web of Science 上进行了广泛搜索，以确定评估 NUP98 重排对 AML 患者预后影响的论文。共有15篇文献、6142名参与者符合本次荟萃分析的要求。我们对所有符合条件的研究进行了检查，以了解总生存期（OS）和无事件生存期（EFS）的HRs和95%置信区间（95%CI）。此外，我们还利用综合荟萃分析软件第 2 版（CMA2）计算了汇总 HRs 和 95% CI：我们的结果：对NUP98-NSD1的分析表明，这种融合会显著影响急性髓细胞白血病患者的预后（汇总HR：2.84；95% CI：2.49-3.24，P=0.000）。此外，我们还观察到 NUP98-KDM5A 重排与急性髓细胞性白血病的不良预后之间存在很强的相关性（汇总 HR：2.65；95% CI：2.5-2.81；P=0.000）。一项亚组分析还显示，NUP98-NSD1和FLT3-ITD共同导致预后不良（汇总HR：2.60；95% CI：1.61-4.18；P=0.000）：NUP98融合可对急性髓细胞性白血病患者的预后产生重大影响。结论：NUP98融合可显著影响急性髓细胞性白血病患者的预后，将这些融合作为急性髓细胞性白血病的预后指标似乎是合理的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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