PD-L1 immunohistochemical expression considering HPV status in oropharyngeal squamous cell carcinoma.

IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Brazilian oral research Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI:10.1590/1807-3107bor-2024.vol38.0095
Raíssa Soares Dos Anjos, Marianne de Vasconcelos Carvalho, Rayanna Thayse Florêncio Costa, Belmiro Cavalcanti do Egito Vasconcelos, Sandra Lúcia Dantas Moraes, Eduardo Piza Pellizzer
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引用次数: 0

Abstract

This systematic review aims to determine whether the presence of human papillomavirus (HPV) influences the immunohistochemical expression of programmed cell death-1 ligand (PD-L1) in oropharyngeal squamous cell carcinoma (OPSCC). PD-L1 immunohistochemical expression varies in OPSCC, and the presence of HPV is a plausible explanation for this variability. Comprehending these findings is crucial, as high PD-L1 expression in the tumor microenvironment of OPSCC can help identify patient subgroups that could be suitable for immunotherapy. Therefore, a systematic review was conducted following PRISMA guidelines (CRD42023437800). An electronic literature search was performed without time or language restrictions. The search included PubMed/MEDLINE, Embase, Scopus, Web of Science, https://clinictrials.gov, and relevant journals. A meta-analysis was performed using RStudio. Fourteen studies involving 1,629 participants were included. The sample consisted predominantly of males (81.26%) with a mean age of 58.3 years. Concerning clinical and pathological characteristics, the most frequently described anatomical location was the tonsils (68.54%), and most participants were either current or former smokers (78%) and alcohol users (79%). Advanced TNM IV was the most common stage. Regarding histopathological characteristics, HPV 16 was the only type mentioned, and half of the cases were detected through immunohistochemistry. The SP142 clone (35.7%) and the pattern of membrane immunostaining in tumor cells (71%) were the most commonly employed methods. The most prevalent findings were positive expression of PD-L1 (64.28%) and negative HPV status (57.14%). The association between PD-L1 positivity and HPV positivity (78.57%) was confirmed by meta-analysis. The conclusion was that HPV-positive status has an impact on immunohistochemical expression of PD-L1 in OPSCC.

口咽鳞癌中考虑 HPV 状态的 PD-L1 免疫组化表达。
本系统综述旨在确定人乳头瘤病毒(HPV)是否会影响口咽鳞状细胞癌(OPSCC)中程序性细胞死亡-1配体(PD-L1)的免疫组化表达。PD-L1在口咽鳞状细胞癌中的免疫组化表达存在差异,而HPV的存在是这种差异的一个合理解释。理解这些发现至关重要,因为 OPSCC 肿瘤微环境中 PD-L1 的高表达有助于识别适合免疫疗法的患者亚群。因此,我们按照PRISMA指南(CRD42023437800)进行了系统性综述。电子文献检索不受时间和语言限制。搜索范围包括 PubMed/MEDLINE、Embase、Scopus、Web of Science、https://clinictrials.gov 以及相关期刊。使用 RStudio 进行了荟萃分析。共纳入 14 项研究,涉及 1629 名参与者。样本主要为男性(81.26%),平均年龄为 58.3 岁。在临床和病理特征方面,最常描述的解剖位置是扁桃体(68.54%),大多数参与者目前或曾经是吸烟者(78%)和饮酒者(79%)。TNM IV 晚期是最常见的分期。在组织病理学特征方面,HPV 16 是唯一被提及的类型,半数病例是通过免疫组化检测到的。SP142克隆(35.7%)和肿瘤细胞膜免疫染色模式(71%)是最常用的方法。最常见的结果是 PD-L1 阳性表达(64.28%)和 HPV 阴性状态(57.14%)。荟萃分析证实了 PD-L1 阳性与 HPV 阳性(78.57%)之间的关联。结论是HPV阳性状态对OPSCC中PD-L1的免疫组化表达有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
4.00%
发文量
107
审稿时长
12 weeks
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