Hyponatremia as a predictor of complicated appendicitis: a systematic review and meta-analysis.

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI:10.1080/17520363.2024.2403332

Huili Shi, Lifang Shen

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引用次数: 0

Abstract

Aim: To investigate the value of hyponatremia as a predictive marker for complicated appendicitis.Methods: PubMed, Embase, Web of Science and Scopus databases were searched for studies published up to 5 June 2024. Studies reporting serum sodium levels in patients with complicated and non-complicated appendicitis and studies reporting the association between baseline hyponatremia and complicated appendicitis were included. A random-effects meta-analysis was performed.Results: Twenty-two studies met the eligibility criteria. Serum sodium levels were measured at arrival or preoperatively in all included studies. Meta-analysis of data from 17 studies showed that preoperative sodium levels were significantly lower in patients with complicated appendicitis vs uncomplicated appendicitis [Mean Difference (MD): -2.58 95% confidence intervals (CI): -3.51, -1.66 I² = 98%]. A pooled analysis of 18 studies demonstrated a statistically significant association between preoperative hyponatremia and complicated appendicitis [Odds Ratio (OR): 4.11 95% CI: 3.07, 5.51 I² = 93%]. Results remained significant on subgroup analysis for adult and pediatric populations. However, the MD was higher and the OR was higher in the subgroup of pediatric patients.Conclusion: Hyponatremia was identified as a potential predictor for complicated appendicitis. The association between hyponatremia and complicated appendicitis seems to be stronger in pediatric patients as compared with adults.

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低钠血症作为复杂性阑尾炎的预测因素：系统综述和荟萃分析。

目的：研究低钠血症作为复杂性阑尾炎预测指标的价值：方法：在 PubMed、Embase、Web of Science 和 Scopus 数据库中检索截至 2024 年 6 月 5 日发表的研究。纳入了报告复杂性和非复杂性阑尾炎患者血清钠水平的研究，以及报告基线低钠血症与复杂性阑尾炎之间关系的研究。进行了随机效应荟萃分析：22项研究符合资格标准。所有纳入的研究都在患者到达时或术前测量了血清钠水平。对 17 项研究数据进行的荟萃分析表明，复杂性阑尾炎患者术前血钠水平明显低于非复杂性阑尾炎患者[平均差 (MD)：-2.58 95% 置信区间 (CI)：-3.51, -1.66 I2 = 98%]。对 18 项研究进行的汇总分析表明，术前低钠血症与复杂性阑尾炎之间存在统计学意义上的显著关联[比值比 (OR)：4.11 95% CI：3.07, 5.51 I2 = 93%]。在对成人和儿童进行亚组分析时，结果仍有意义。然而，儿科患者亚组的MD更高，OR也更高：结论：低钠血症是复杂性阑尾炎的潜在预测因素。结论：低钠血症被认为是复杂性阑尾炎的潜在预测因素，与成人相比，低钠血症与复杂性阑尾炎之间的关系在儿童患者中似乎更为密切。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.