A simple and efficient method for separation of 99mTc from 100Mo targets

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2024-09-25 DOI:10.1016/j.apradiso.2024.111531

Desheng Chen , Qinggang Huang , Shiwei Cao , Xiaolei Wu , Wei Tian , Cunmin Tan , Jieru Wang , Mu Lin , Zhi Qin

引用次数: 0

Abstract

^99mTc is regarded as the most important medical isotope, and its supply issues have garnered significant attention. A simple and efficient separation method was performed for the production of ^99mTc from ¹⁰⁰Mo target in this study. The entire process involves accelerator irradiation, ^99mTc/¹⁰⁰Mo separation, and target material recovery. The key aspect is separation process, which including the high-temperature conversion of metal molybdenum targets and the selective solution of ^99mTc with normal saline. This method can separate highly pure ^99mTc within 1.5 h, with a separation efficiency exceeding 80%. The reagents used in the separation process are minimal, resulting in less radioactive waste. Additionally, the target material is easy to reclaim, with a recovery rate of over 95%.

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从 100Mo 靶件中分离 99mTc 的简单高效方法。

99mTc 被视为最重要的医用同位素，其供应问题备受关注。本研究采用一种简单高效的分离方法，从 100Mo 靶件中生产 99m锝。整个过程包括加速器辐照、99mTc/100Mo 分离和靶材料回收。其中最关键的是分离过程，包括金属钼靶的高温转化和 99mTc 与生理盐水的选择性溶解。该方法可在 1.5 小时内分离出高纯度的 99m锝，分离效率超过 80%。分离过程中使用的试剂极少，从而减少了放射性废物。此外，目标材料易于回收，回收率超过 95%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.