Bridging brain insulin resistance to Alzheimer's pathogenesis.

IF 3.5 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Biology Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.1016/j.tibs.2024.09.004

Wenqiang Chen, Valdemar Brimnes Ingemann Johansen, Cristina Legido-Quigley

引用次数: 0

Abstract

Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3β (GSK3β) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.

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将大脑胰岛素抵抗与阿尔茨海默氏症发病机制联系起来。

越来越多的证据表明，2 型糖尿病（T2DM）和阿尔茨海默病（AD）之间存在联系，而脑胰岛素抵抗（BIR）是其中的一个关键因素。在最近的一项研究中，Lanzillotta 等人发现，胆绿素还原酶-A（BVR-A）的减少会损害糖原合成酶激酶 3β （GSK3β）的磷酸化，导致线粒体功能障碍，并在 T2DM 和 AD 的进展过程中加剧脑胰岛素抵抗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Chemical Biology 生物-生化与分子生物学

CiteScore

7.50

自引率

5.00%

发文量

353

审稿时长

3.3 months

期刊介绍： ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.