Multifunctional Hydrogel Microneedle Patches Modulating Oxi-inflamm-aging for Diabetic Wound Healing.

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2024-10-03 DOI:10.1002/smll.202407340

Shen Tian, Jiawei Mei, Lisha Zhang, Senyan Wang, Yuhui Yuan, Jia Li, Hongjian Liu, Wanbo Zhu, Dongdong Xu

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Abstract

Oxidative stress, chronic inflammation, and immune senescence are important pathologic factors in diabetic wound nonhealing. This study loads taurine (Tau) into cerium dioxide (CeO₂) to develop CeO₂@Tau nanoparticles with excellent antioxidant, anti-inflammatory, and anti-aging properties. To enhance the drug penetration efficiency in wounds, CeO₂@Tau is encapsulated in gelatin methacryloyl (GelMA) hydrogel to prepare CeO₂@Tau@Hydrogel@Microneedle (CTH@MN) patch system. Microneedle technology achieves precise and efficient delivery of CeO₂@Tau, ensuring their deep penetration into the wound tissue for optimal efficacy. Rigorous in vitro and in vivo tests have confirmed the satisfactory therapeutic effect of CTH@MN patch on diabetic wound healing. Mechanistically, CTH@MN attenuates oxidative damage and inflammatory responses in macrophages by inhibiting the ROS/NF-κB signaling pathway. Meanwhile, CTH@MN activated autophagy-mediated anti-aging activity, creating a favorable immune microenvironment for tissue repair. Notably, in a diabetic mouse wound model, the multifunctional CTH@MN patch significantly promotes wound healing by systematically regulating the oxidation-inflammation-aging (oxi-inflamm-aging) pathological axis. In conclusion, the in-depth exploration of the CTH@MN system in this study provides new strategies and perspectives for treating diabetic non-healing wounds.

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多功能水凝胶微针贴片调节氧化-炎症-老化，促进糖尿病伤口愈合

氧化应激、慢性炎症和免疫衰老是糖尿病伤口不愈合的重要病理因素。本研究将牛磺酸（Tau）添加到二氧化铈（CeO2）中，开发出具有卓越抗氧化、抗炎和抗衰老特性的 CeO2@Tau 纳米粒子。为了提高药物在伤口中的渗透效率，将 CeO2@Tau 包裹在明胶甲基丙烯酰（GelMA）水凝胶中，制备出 CeO2@Tau@Hydrogel@Microneedle (CTH@MN) 贴片系统。微针技术实现了 CeO2@Tau 的精确、高效输送，确保其深入伤口组织，达到最佳疗效。严格的体外和体内试验证实，CTH@MN贴片对糖尿病伤口愈合具有令人满意的治疗效果。从机理上讲，CTH@MN 通过抑制 ROS/NF-κB 信号通路，减轻巨噬细胞的氧化损伤和炎症反应。同时，CTH@MN 激活了自噬介导的抗衰老活性，为组织修复创造了有利的免疫微环境。值得注意的是，在糖尿病小鼠伤口模型中，多功能 CTH@MN 贴片通过系统调节氧化-炎症-衰老（oxi-inflammation-aging）病理轴，显著促进了伤口愈合。总之，本研究对 CTH@MN 系统的深入探索为治疗糖尿病不愈合伤口提供了新的策略和视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.