Non-Invasive Serum Markers of Non-Alcoholic Fatty Liver Disease Fibrosis: Potential Tools for Detecting Patients with Cardiovascular Disease.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-24 eCollection Date: 2024-09-01 DOI:10.31083/j.rcm2509344

Ling-Zi Chen, Xu-Bin Jing, Xiang Chen, Yan-Chun Xie, Yun Chen, Xian-Bin Cai

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引用次数: 0

Abstract

Non-alcoholic fatty liver disease (NAFLD), one of the most common chronic liver diseases with a prevalence of 23%-25% globally, is an independent risk factor for cardiovascular diseases (CVDs). Growing evidence indicates that the development of NAFLD, ranging from non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), advanced fibrosis to cirrhosis, and even hepatocellular carcinoma, is at substantial risk for CVDs, which clinically contribute to increased cardiovascular morbidity and mortality. Non-invasive serum markers assessing liver fibrosis, such as fibrosis-4 (FIB-4) score, aspartate transaminase-to-platelet ratio index (APRI), and NAFLD fibrosis score (NFS), are expected to be useful tools for clinical management of patients with CVDs. This review aims to provide an overview of the evidence for the relationship between the progression of NAFLD and CVDs and the clinical application of non-invasive markers of liver fibrosis in managing patients with CVDs.

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非酒精性脂肪肝纤维化的非侵入性血清标志物：检测心血管疾病患者的潜在工具。

非酒精性脂肪肝（NAFLD）是最常见的慢性肝病之一，全球发病率为 23%-25%，是心血管疾病（CVDs）的独立危险因素。越来越多的证据表明，从非酒精性脂肪肝（NAFL）、非酒精性脂肪性肝炎（NASH）、晚期肝纤维化到肝硬化，甚至肝细胞癌，非酒精性脂肪肝的发展是心血管疾病的重要风险因素，在临床上导致心血管疾病的发病率和死亡率增加。评估肝纤维化的无创血清标志物，如肝纤维化-4（FIB-4）评分、天冬氨酸转氨酶与血小板比值指数（APRI）和非酒精性脂肪肝纤维化评分（NFS），有望成为心血管疾病患者临床管理的有用工具。本综述旨在概述非酒精性脂肪肝进展与心血管疾病之间关系的证据，以及肝纤维化无创标记物在心血管疾病患者管理中的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.