Mortality associated with clozapine: what is the evidence?

IF 8.7 1区医学 Q1 PSYCHIATRY

British Journal of Psychiatry Pub Date : 2024-09-01 DOI:10.1192/bjp.2024.88

Emilio Fernandez-Egea, Robert J Flanagan, David Taylor, Fiona Gaughran, Stephen M Lawrie, Christopher Jenkins, Shubulade Smith, Oliver D Howes, James H MacCabe

引用次数: 0

Abstract

While clozapine has risks, relative risk of fatality is overestimated. The UK pharmacovigilance programme is efficient, but comparisons with other drugs can mislead because of reporting variations. Clozapine actually lowers mortality, partly by reducing schizophrenia-related suicides, but preventable deaths still occur. Clozapine should be used earlier and more widely, but there should be better monitoring and better management of toxicity.

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与氯氮平相关的死亡率：证据是什么？

虽然氯氮平有风险，但死亡的相对风险被高估了。英国的药物警戒计划效率很高，但由于报告的差异，与其他药物的比较可能会产生误导。氯氮平实际上降低了死亡率，部分原因是减少了与精神分裂症有关的自杀，但仍有可预防的死亡发生。氯氮平应该更早、更广泛地使用，但应该更好地监测和管理毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Psychiatry 医学-精神病学

CiteScore

13.70

自引率

1.90%

发文量

184

审稿时长

4-8 weeks

期刊介绍： The British Journal of Psychiatry (BJPsych) is a renowned international journal that undergoes rigorous peer review. It covers various branches of psychiatry, with a specific focus on the clinical aspects of each topic. Published monthly by the Royal College of Psychiatrists, this journal is dedicated to enhancing the prevention, investigation, diagnosis, treatment, and care of mental illness worldwide. It also strives to promote global mental health. In addition to featuring authoritative original research articles from across the globe, the journal includes editorials, review articles, commentaries on contentious issues, a comprehensive book review section, and a dynamic correspondence column. BJPsych is an essential source of information for psychiatrists, clinical psychologists, and other professionals interested in mental health.