The Molecular Mechanism of Macrophages in Response to Mechanical Stress.

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL
Yuntong Su, Xing Yin
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引用次数: 0

Abstract

Macrophages, a type of functionally diversified immune cell involved in the progression of many physiologies and pathologies, could be mechanically activated. The physical properties of biomaterials including stiffness and topography have been recognized as exerting a considerable influence on macrophage behaviors, such as adhesion, migration, proliferation, and polarization. Recent articles and reviews on the physical and mechanical cues that regulate the macrophage's behavior are available; however, the underlying mechanism still deserves further investigation. Here, we summarized the molecular mechanism of macrophage behavior through three parts, as follows: (1) mechanosensing on the cell membrane, (2) mechanotransmission by the cytoskeleton, (3) mechanotransduction in the nucleus. Finally, the present challenges in understanding the mechanism were also noted. In this review, we clarified the associated mechanism of the macrophage mechanotransduction pathway which could provide mechanistic insights into the development of treatment for diseases like bone-related diseases as molecular targets become possible.

巨噬细胞应对机械压力的分子机制
巨噬细胞是一种功能多样化的免疫细胞,参与了许多生理和病理过程,可被机械激活。生物材料的物理特性(包括硬度和形貌)被认为对巨噬细胞的行为(如粘附、迁移、增殖和极化)有相当大的影响。最近有一些关于调控巨噬细胞行为的物理和机械线索的文章和综述,但其潜在机制仍值得进一步研究。在此,我们通过以下三个部分总结了巨噬细胞行为的分子机制:(1)细胞膜上的机械感应;(2)细胞骨架的机械传递;(3)细胞核内的机械传导。最后,我们还指出了目前在理解该机制方面所面临的挑战。在这篇综述中,我们阐明了巨噬细胞机械传导途径的相关机制,随着分子靶点成为可能,这将为开发治疗骨相关疾病等疾病的方法提供机制上的启示。
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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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