Risk factors for the neurodegenerative dementias in the Western Pacific region

IF 7.6 1区医学 Q1 HEALTH CARE SCIENCES & SERVICES

The Lancet Regional Health: Western Pacific Pub Date : 2024-09-01 DOI:10.1016/j.lanwpc.2024.101051

Antonia J. Clarke , Amy Brodtmann , Muireann Irish , Loren Mowszowski , Kylie Radford , Sharon L. Naismith , Vincent C.T. Mok , Matthew C. Kiernan , Glenda M. Halliday , Rebekah M. Ahmed

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Abstract

The Western Pacific Region (WPR) is characterized by a group of socioeconomically, culturally, and geopolitically heterogenous countries and represents a microcosm of the global endemic of neurodegeneration. This review will chart the known risk factors for dementia across the WPR. We explore the intersection between the established risk factors for dementia including the biomedical and lifestyle (cardiovascular and metabolic disease, sleep, hearing loss, depression, alcohol, smoking, traumatic brain injury, genetics) and social determinants (social disadvantage, limited education, systemic racism) as well as incorporate neuroimaging data, where available, to predict disease progression in the WPR. In doing so, we highlight core risk factors for dementia in the WPR, as well as geographical epicentres at heightened risk for dementia, to orient future research towards addressing these disparities.

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西太平洋地区神经退行性痴呆症的风险因素

西太平洋地区（WPR）的特点是社会经济、文化和地缘政治各不相同，是全球神经变性流行病的一个缩影。本综述将列出世界痴呆症流行地区的已知痴呆症风险因素。我们将探讨已确定的痴呆症风险因素之间的交叉点，包括生物医学和生活方式（心血管和代谢疾病、睡眠、听力损失、抑郁、酗酒、吸烟、脑外伤、遗传学）以及社会决定因素（社会不利条件、有限的教育、系统性种族主义），并结合现有的神经影像学数据来预测世界人口研究计划中的疾病进展。在此过程中，我们强调了 WPR 中痴呆症的核心风险因素，以及痴呆症高风险的地理中心，以引导未来的研究解决这些差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Lancet Regional Health: Western Pacific Medicine-Pediatrics, Perinatology and Child Health

CiteScore

8.80

自引率

2.80%

发文量

305

审稿时长

11 weeks

期刊介绍： The Lancet Regional Health – Western Pacific, a gold open access journal, is an integral part of The Lancet's global initiative advocating for healthcare quality and access worldwide. It aims to advance clinical practice and health policy in the Western Pacific region, contributing to enhanced health outcomes. The journal publishes high-quality original research shedding light on clinical practice and health policy in the region. It also includes reviews, commentaries, and opinion pieces covering diverse regional health topics, such as infectious diseases, non-communicable diseases, child and adolescent health, maternal and reproductive health, aging health, mental health, the health workforce and systems, and health policy.