{"title":"Emerging trends in plant natural products biosynthesis: a chemical perspective","authors":"Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir","doi":"10.1016/j.pbi.2024.102649","DOIUrl":null,"url":null,"abstract":"<div><div>Biosynthetic pathways are multistep processes transforming simple substrates into more complex structures. Over the past two decades, our understanding of these pathways, especially for specialized plant metabolites, has significantly increased. This surge is due to numerous scientific advancements such as next-generation sequencing, improved analytical platforms, and metabolite-transcript networks. The uprising of data sharing through public databases has also fostered collaboration and knowledge dissemination. Growing concerns about the supply of therapeutic natural products and their environmental impact have led to exploring sustainable alternatives like heterologous expression, which requires extensive knowledge of these pathways. Herein, we review emerging approaches in biosynthetic pathway elucidations and their prospects for their efficient integration.</div></div>","PeriodicalId":11003,"journal":{"name":"Current opinion in plant biology","volume":"82 ","pages":"Article 102649"},"PeriodicalIF":8.3000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in plant biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369526624001407","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Biosynthetic pathways are multistep processes transforming simple substrates into more complex structures. Over the past two decades, our understanding of these pathways, especially for specialized plant metabolites, has significantly increased. This surge is due to numerous scientific advancements such as next-generation sequencing, improved analytical platforms, and metabolite-transcript networks. The uprising of data sharing through public databases has also fostered collaboration and knowledge dissemination. Growing concerns about the supply of therapeutic natural products and their environmental impact have led to exploring sustainable alternatives like heterologous expression, which requires extensive knowledge of these pathways. Herein, we review emerging approaches in biosynthetic pathway elucidations and their prospects for their efficient integration.
期刊介绍:
Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.