Nanomedicine breakthrough: Cyclodextrin-based nano sponges revolutionizing cancer treatment

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2024-09-28 DOI:10.1016/j.nanoso.2024.101358

Devesh U. Kapoor , Rahul Garg , Pushpendra Kumar Saini , Mansi Gaur , Bhupendra G. Prajapati

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引用次数: 0

Abstract

Cyclodextrin based Nanosponges (““CDX” ”-“NSP”) is a versatile platform for cancer treatment. The unique advantages of “CDX”, such as biocompatibility, low surface area and the ability to form inclusion complexes. “CDX” is synthesized through a cross-linking process to create a three-dimensional network for encapsulating and protecting anticancer drugs. ““CDX” ” “NSP” can exhibit either a crystalline or amorphous structure, along with a spherical shape and notable swelling properties. These “NSP” can complex with a diverse range of molecules with a diverse range of lipophilic or hydrophilic molecules. Characterization techniques, including spectroscopy and morphological studies, ensure the reproducibility and reliability of “CDX” “NSP”, shedding light on their stability and drug-loading capabilities. The versatility of “CDX” “NSP” showcases its potential as a universal drug delivery platform adaptable to various malignancies.

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纳米医学的突破：基于环糊精的纳米海绵为癌症治疗带来变革

基于环糊精的纳米海绵（"CDX"-"NSP"）是治疗癌症的多功能平台。CDX "具有生物相容性、低表面积和形成包涵复合物的能力等独特优势。"CDX" 是通过交联工艺合成的，可形成三维网络，用于包裹和保护抗癌药物。"CDX""NSP "可以呈现结晶或无定形结构，并具有球形和显著的膨胀特性。这些 "NSP "可与多种分子复合，其中包括多种亲油或亲水分子。包括光谱和形态研究在内的表征技术确保了 "CDX""NSP "的可重复性和可靠性，并揭示了其稳定性和药物负载能力。CDX""NSP "的多功能性展示了其作为通用给药平台的潜力，可适用于各种恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .