Indocyanine green and methylene blue dye guided sentinel lymph node biopsy in patients with penile cancer (PeCa): results of 50 inguinal basins assessed at a single institution in India.

IF 2.8 2区 医学 Q2 UROLOGY & NEPHROLOGY
Mohan Amaresh, Rakesh M Sharma, Anupam Choudhary, Abhijit Shah, B Vishal Rao, Thammineedi Subramanyeshwar Rao
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Abstract

Aim: The primary aim of this study was to validate the reliability, sensitivity and safety profile of novel combination of ICG- methylene blue dye as an SN tracer for PeCa.

Methods: This is a validation and non-randomised prospective observational study involving 25 patients (50 inguinal basins) who underwent SLNB where in ICG and methylene blue were used for localisation. The patients with clinically node negative groins were recruited in the study. SNs were identified intraoperatively using near infrared fluorescence imaging (NIRF Imaging system, SPY-PHI, Stryker, Sweden) and blue dye. The numbers of SNs identified by each tracer and the rates of complications and nodal recurrence during the followup.

Results: Overall 137 SNs were identified intraoperatively. Among the 137 SNs excised fluorescence, blue dye and Combined (blue + green) identified 57(41.6%), 27 (19.7%), and 51 (37.2%), respectively. The average number of SLNs removed per patient was 5 (range, 1-11) with sentinel lymph nodes detection rate at 94% (47/50). Seven patients had malignancy on SLNB and underwent ipsilateral radical inguinal lymphadenectomy. One patient had false negative SN and positive node in modified inguinal lymphadenectomy specimen. No adverse events were observed in all cases.

Conclusion: The Novel combination of ICG fluorescence-Methylene blue dye technique is simple, reliable and safe. Moreover, it demonstrates a high SLN detection rate with a low false-negative rate, and it avoids radiation exposure.

吲哚菁绿和亚甲蓝染料引导的阴茎癌(PeCa)患者前哨淋巴结活检:印度一家机构对 50 个腹股沟盆地的评估结果。
目的:本研究的主要目的是验证 ICG 和亚甲蓝染料新型组合作为 PeCa SN 示踪剂的可靠性、灵敏度和安全性:这是一项验证性非随机前瞻性观察研究,共有 25 名患者(50 个腹股沟盆腔)接受了 SLNB,其中 ICG 和亚甲蓝被用于定位。研究招募了腹股沟临床结节阴性的患者。术中使用近红外荧光成像系统(NIRF 成像系统,SPY-PHI,史赛克,瑞典)和蓝色染料识别 SN。随访期间,每种示踪剂确定的SN数量以及并发症和结节复发率:结果:术中共发现137个SN。在切除的137个SN中,荧光、蓝色染料和联合(蓝+绿)分别识别出57个(41.6%)、27个(19.7%)和51个(37.2%)。每位患者切除的前哨淋巴结平均为 5 个(1-11 个不等),前哨淋巴结检出率为 94%(47/50)。有七名患者的前哨淋巴结出现恶变,接受了同侧腹股沟根治性淋巴结切除术。一名患者在改良腹股沟淋巴结切除术标本中出现 SN 假阴性和结节阳性。所有病例均未出现不良反应:新颖的 ICG 荧光-亚甲蓝染料组合技术简单、可靠、安全。结论:ICG 荧光-亚甲蓝染料新技术简单、可靠、安全,而且 SLN 检出率高、假阴性率低,还避免了放射线照射。
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来源期刊
World Journal of Urology
World Journal of Urology 医学-泌尿学与肾脏学
CiteScore
6.80
自引率
8.80%
发文量
317
审稿时长
4-8 weeks
期刊介绍: The WORLD JOURNAL OF UROLOGY conveys regularly the essential results of urological research and their practical and clinical relevance to a broad audience of urologists in research and clinical practice. In order to guarantee a balanced program, articles are published to reflect the developments in all fields of urology on an internationally advanced level. Each issue treats a main topic in review articles of invited international experts. Free papers are unrelated articles to the main topic.
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