Hair fragility (trichorrhexis nodosa) in alopecic Pomeranian dogs.

IF 1.9 3区 农林科学 Q3 DERMATOLOGY
Erin Brennan, Jonna Juhola, Ewan A Ferguson, Anette Loeffler, Rosario Cerundolo, Anke Hendricks, Ross Bond
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Abstract

Background: While alopecia associated with hair cycle arrest (HCA, Alopecia X) is well-recognised in Pomeranian dogs, the authors are unaware of reports of concurrent hair fragility.

Hypothesis/objectives: Following the observation of frequent hair shaft abnormalities in alopecic Pomeranians, we hypothesised that hair fragility events would be more frequent in dogs with a phenotype of HCA when compared to dogs with normal coats.

Animals: Eight alopecic Pomeranian dogs or crosses with a phenotype of HCA and 36 unaffected Pomeranians with owner-reported normal hair coats.

Materials and methods: All affected dogs underwent dermatological examination and clinicopathological evaluations. Hair samples, plucked from affected areas or obtained by brushing from unaffected dogs, were examined microscopically for structural abnormalities. Hair fragility events were characterised as trichorrhexis nodosa (TN) or longitudinal splits and were expressed per 10 mg of hair. A reference interval was calculated from the number of hair fragility events in the samples from unaffected dogs.

Results: The upper reference limit (with 90% confidence) from samples of 35 unaffected Pomeranians (one outlier excluded) was 9.75 hair fragility events per 10 mg of hair. The median (range) of fragility events in eight dogs with a phenotype of HCA was 66.0 (30.2-166.7) per 10 mg of hair.

Conclusions and clinical relevance: Clinicians should routinely perform trichography in Pomeranians with HCA because abundant hair abnormalities, particularly TN, may contribute to poor hair coat quality. Further studies are required to establish the pathophysiology of and treatments for these fragility events and to determine their predictive value for HCA.

患有脱毛症的博美犬毛发脆弱(结节性毛囊炎)。
背景:在博美犬中,与毛发周期停滞(HCA,Alopecia X)相关的脱发已被广泛认可,但作者并不知道有关于同时出现毛发脆弱的报道:在观察到脱毛博美犬的毛干经常出现异常后,我们假设,与毛发正常的博美犬相比,具有 HCA 表型的博美犬毛发脆弱的情况会更加频繁:动物:8 只表型为 HCA 的脱毛博美犬或杂交犬,以及 36 只未受影响且主人报告毛发正常的博美犬:所有患病犬均接受了皮肤病学检查和临床病理学评估。从患病部位拔下的毛发样本或从未受损伤的狗身上刷下的毛发样本都在显微镜下进行了结构异常检查。毛发脆性事件的特征为结节性毛囊炎(TN)或纵向劈裂,并以每 10 毫克毛发表示。根据未受影响犬样本中毛发脆性事件的数量计算出参考区间:从 35 只未受影响的博美犬(排除了一个异常值)的样本中得出的参考上限(置信度为 90%)为每 10 毫克毛发中有 9.75 个毛发脆性事件。8 只具有 HCA 表型的狗的毛发脆性事件中位数(范围)为每 10 毫克毛发 66.0(30.2-166.7)次:临床医生应定期对患有 HCA 的博美犬进行毛发染色,因为大量毛发异常(尤其是 TN)可能会导致毛发质量低下。需要进一步研究以确定这些脆性事件的病理生理学和治疗方法,并确定它们对 HCA 的预测价值。
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来源期刊
Veterinary dermatology
Veterinary dermatology 农林科学-兽医学
CiteScore
3.20
自引率
21.40%
发文量
92
审稿时长
12-24 weeks
期刊介绍: Veterinary Dermatology is a bi-monthly, peer-reviewed, international journal which publishes papers on all aspects of the skin of mammals, birds, reptiles, amphibians and fish. Scientific research papers, clinical case reports and reviews covering the following aspects of dermatology will be considered for publication: -Skin structure (anatomy, histology, ultrastructure) -Skin function (physiology, biochemistry, pharmacology, immunology, genetics) -Skin microbiology and parasitology -Dermatopathology -Pathogenesis, diagnosis and treatment of skin diseases -New disease entities
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