The double play of a phage HTH regulator.

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI:10.1016/j.tim.2024.09.005

Zacharie Morneau, Sylvain Moineau

引用次数: 0

Abstract

Bacteriophages use anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems. The expression of Acr is regulated by anti-CRISPR-associated (Aca) proteins, which are helix-turn-helix (HTH) repressors that bind DNA. Recently, Birkholz et al. discovered that an Aca can also repress Acr expression by binding RNA, revealing a new function for HTH repressors.

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噬菌体 HTH 调节器的双重作用。

噬菌体利用抗 CRISPR（Acr）蛋白来抑制 CRISPR-Cas 系统。Acr的表达受抗CRISPR相关（Aca）蛋白的调控，后者是一种结合DNA的螺旋-转螺旋（HTH）抑制因子。最近，Birkholz 等人发现，Aca 还能通过结合 RNA 来抑制 Acr 的表达，这揭示了 HTH 抑制因子的一种新功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.