Patterns of soil-transmitted helminth aggregation in the human host population after several years of intensive mass drug administration.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-12-03 DOI:10.1093/trstmh/trae059

Julia Mayer, Benjamin S Collyer, Rosie Maddren, Birhan Abtew, Ewnetu Firdawek Liyew, Melkie Chernet, Getachew Tollera, Geremew Tasew, Roy M Anderson

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Abstract

Background: Community-wide mass drug administration (cMDA) is known as an effective, albeit costly, control strategy for soil-transmitted helminth (STH) parasites. A better understanding of STH aggregation after many rounds of cMDA could help shape more cost-effective policies.

Methods: This analysis uses data from the Geshiyaro project, aiming to break STH transmission by cMDA and water, sanitation and hygiene interventions. Ascaris lumbricoides infection prevalence is derived from egg count data and parasite aggregation is obtained by fitting a negative binomial distribution to the frequency distribution of faecal egg counts.

Results: The relationship between parasite dispersion and infection prevalence is approximately linear. Parasite aggregation increases as infection prevalence decreases.

Conclusions: A minority of individuals carry most parasites as prevalence decreases in the community. These individuals could be selectively targeted for repeated treatment.

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经过数年大规模密集用药后，人类宿主群体中土壤传播蠕虫的聚集模式。

背景：众所周知，全社区大规模用药（cMDA）是一种有效的控制土壤传播蠕虫（STH）寄生虫的策略，尽管成本高昂。更好地了解多轮 cMDA 后 STH 的聚集情况有助于制定更具成本效益的政策：本分析采用了 Geshiyaro 项目的数据，该项目旨在通过 cMDA 以及水、环境卫生和个人卫生干预措施来阻止 STH 传播。蛔虫感染率来自虫卵计数数据，寄生虫聚集度则是通过对粪便虫卵计数的频率分布拟合负二项分布得到的：结果：寄生虫分布与感染率之间的关系近似线性。寄生虫聚集度随着感染率的降低而增加：结论：随着社区中寄生虫感染率的降低，少数人携带大部分寄生虫。可以有选择地对这些人进行反复治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.