Treatment selection pattern and prognostic factors in older patients with non-small cell lung cancer at recurrence: an observational study.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2024-09-27 DOI:10.1007/s00595-024-02938-3

Dai Sonoda, Raito Maruyama, Yasuto Kondo, Masahito Naito, Masashi Mikubo, Kazu Shiomi, Yukitoshi Satoh

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Abstract

Purpose: Society is aging, and the proportion of older patients with lung cancer is increasing. However, the treatment choices and prognoses for older patients with cancer recurrence remain unclear. We retrospectively investigated the treatment choices and prognoses of older patients with recurrence.

Methods: We conducted a retrospective review of 1100 patients who underwent complete resection for non-small cell lung cancer at Kitasato University Hospital between 2004 and 2017. Patients of ≥75 years of age were defined as older patients, and the prognosis and prognostic factors of these patients upon recurrence were examined.

Results: Among the 290 patients who developed recurrence, 106 experienced recurrence at an older age. The factors associated with survival after recurrence included sex, time to recurrence, number of recurrences, performance status at recurrence, and active treatment. As the age at recurrence increased, the proportion of patients who did not receive active treatment increased, as did the proportion for whom the reason was the patient's and family's preferences.

Conclusions: A considerable number of older patients who experience recurrence do not wish to receive active treatment. However, the prognosis can be improved by aggressive treatment for recurrence.

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老年非小细胞肺癌复发患者的治疗选择模式和预后因素：一项观察性研究。

目的：社会正在老龄化，老年肺癌患者的比例也在增加。然而，老年癌症复发患者的治疗选择和预后仍不明确。我们对老年复发患者的治疗选择和预后进行了回顾性研究：我们对 2004 年至 2017 年期间在北里大学医院接受非小细胞肺癌完全切除术的 1100 例患者进行了回顾性研究。将年龄≥75岁的患者定义为老年患者，并研究了这些患者复发后的预后情况和预后因素：在复发的290名患者中，有106名患者的复发年龄较大。与复发后存活率相关的因素包括性别、复发时间、复发次数、复发时的表现状态和积极治疗。随着复发年龄的增加，未接受积极治疗的患者比例也在增加，而患者和家属的意愿也在增加：结论：相当多的复发老年患者不希望接受积极治疗。然而，积极治疗复发可改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.