Sleep state-dependent development of resting state functional connectivity during the preterm period.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-09-25 DOI:10.1093/sleep/zsae225

Anna Shiraki, Hiroyuki Kidokoro, Hama Watanabe, Gentaro Taga, Takafumi Ushida, Hajime Narita, Takamasa Mitsumatsu, Sumire Kumai, Ryosuke Suzui, Fumi Sawamura, Yuji Ito, Hiroyuki Yamamoto, Tomohiko Nakata, Yoshiaki Sato, Masahiro Hayakawa, Yoshiyuki Takahashi, Jun Natsume

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引用次数: 0

Abstract

Study objectives: The brains of preterm infants exhibit altered functional connectivity (FC) networks, but the potential variation in sleep states and the impact of breathing patterns on FC networks are unclear. This study explores the evolution of resting-state FC from preterm to term, focusing on breathing patterns and distinguishing between active sleep and quiet sleep.

Methods: We recruited 63 preterm infants and 44 healthy-term infants and performed simultaneous electroencephalography and functional near-infrared spectroscopy. FC was calculated using oxy- and deoxyhemoglobin signals across eight channels. First, FC was compared between periodic breathing (PB) and non-PB segments. Then sleep state-dependent FC development was explored. FC was compared between active sleep and quiet sleep segments and between preterm infants at term and term-born infants in each sleep state. Finally, associations between FC at term, clinical characteristics, and neurodevelopmental outcomes in late infancy were assessed in preterm infants.

Results: In total, 148 records from preterm infants and 44 from term-born infants were analyzed. PB inflated FC values. After excluding PB segments, FC was found to be elevated during active sleep compared to quiet sleep, particularly in connections involving occipital regions. Preterm infants had significantly higher FC in both sleep states compared to term-born infants. Furthermore, stronger FC in specific connections during active sleep at term was associated with unfavorable neurodevelopment in preterm infants.

Conclusions: Sleep states play a critical role in FC development and preterm infants show observable changes in FC.

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早产儿静息状态功能连接的发展与睡眠状态有关。

研究目的早产儿大脑的功能连接（FC）网络发生了改变，但睡眠状态的潜在变化以及呼吸模式对FC网络的影响尚不清楚。本研究探讨了从早产儿到足月儿静息态功能连接的演变，重点关注呼吸模式，并区分活跃睡眠和安静睡眠：我们招募了 63 名早产儿和 44 名健康足月儿，并同时进行了脑电图和功能性近红外光谱分析。利用八个通道的氧合血红蛋白和脱氧血红蛋白信号计算FC。首先，比较了周期性呼吸（PB）和非 PB 段的 FC。然后，探讨了睡眠状态对 FC 发展的影响。比较了活跃睡眠段和安静睡眠段之间的 FC，以及足月早产儿和足月出生婴儿在每种睡眠状态下的 FC。最后，对早产儿足月时的FC、临床特征和婴儿后期神经发育结果之间的关联进行了评估：结果：共分析了 148 份早产儿记录和 44 份足月儿记录。PB 使 FC 值升高。在剔除PB片段后，发现与安静睡眠相比，活跃睡眠时的FC值升高，尤其是在涉及枕叶区域的连接中。早产儿在两种睡眠状态下的 FC 值都明显高于足月儿。此外，早产儿在活跃睡眠状态下特定连接中更强的FC与早产儿不利的神经发育有关：结论：睡眠状态在FC发育中起着关键作用，早产儿的FC会出现明显变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.