Phenotypic variations in knee osteoarthritis: insights from MRI and radiographic comparisons.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-30 DOI:10.1007/s00256-024-04807-z

Ozgur Tosun, Kazim Ayberk Sinci, Caner Baysan, Yasemin Kucukciloglu, Mehmet Aksit, Cemal Kazimoglu, Gokay Karaca, Atilla Hikmet Cilengir

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引用次数: 0

Abstract

Objective: To investigate the correlation between MRI-based phenotypes (cartilage-meniscus, subchondral bone, and inflammatory) and radiography-based atrophic and hypertrophic phenotypes, aiming to demonstrate MRI's diagnostic capability in identifying complex osteoarthritis phenotypes that radiography cannot fully capture.

Materials and methods: This single-center retrospective study examined knee radiographs and MRIs of patients from November 2021 to April 2023 to identify osteoarthritis phenotypes. Radiographs were staged by the Kellgren-Lawrence system, and both modalities were classified into atrophic or hypertrophic phenotypes. MRIs were further classified into three phenotypes: cartilage-meniscus, subchondral bone, and inflammatory. Associations between phenotypes, Kellgren-Lawrence stage, age, and gender were analyzed with Pearson chi-square test and student T-test. Reliability measurements were evaluated using kappa statistic.

Results: A total of 214 knees from 187 individuals (73.3% women, 26.7% men; mean age 57.1 ± 9.1 years) were included. The hypertrophic MRI phenotype was significantly associated with cartilage-meniscus and subchondral bone phenotypes (p < 0.001). Cartilage-meniscus and subchondral bone phenotypes were less prevalent in Kellgren-Lawrence stage 2 than in stages 3 and 4 (p < 0.001 and p = 0.004, respectively). The subchondral bone phenotype was more common in men (p = 0.022), and the cartilage-meniscus phenotype in the elderly (p < 0.001). Radiography and MRI had substantial agreement (Kappa = 0.637, p < 0.001) in diagnosing hypertrophic and atrophic phenotypes.

Conclusion: The hypertrophic phenotype was associated with cartilage-meniscus and subchondral bone phenotypes, with lower prevalences in Kellgren-Lawrence stage 2 knees. MRI offers enhanced phenotypic characterization, which facilitates more precise and individualized management in osteoarthritis care. Despite limitations compared to MRI, radiography remains valuable for the evaluation of hypertrophic and atrophic phenotypes.

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膝关节骨性关节炎的表型变异：从核磁共振成像和影像学比较中获得的启示。

目的研究基于核磁共振成像的表型（软骨-半月板、软骨下骨和炎症）与基于X光片的萎缩和肥厚表型之间的相关性，旨在证明核磁共振成像在识别X光片无法完全捕捉的复杂骨关节炎表型方面的诊断能力：这项单中心回顾性研究检查了2021年11月至2023年4月期间患者的膝关节X光片和核磁共振成像，以确定骨关节炎表型。根据 Kellgren-Lawrence 系统对射线照片进行分期，并将两种模式分为萎缩表型和肥厚表型。核磁共振成像进一步分为三种表型：软骨-半月板型、软骨下骨型和炎症型。表型、Kellgren-Lawrence分期、年龄和性别之间的关联采用皮尔逊卡方检验和学生T检验进行分析。使用卡帕统计量评估测量的可靠性：结果：共纳入了 187 人（73.3% 为女性，26.7% 为男性；平均年龄为 57.1 ± 9.1 岁）的 214 个膝关节。肥厚型 MRI 表型与软骨-半月板和软骨下骨表型显著相关（p 结论：肥厚型 MRI 表型与软骨-半月板和软骨下骨表型显著相关：肥厚表型与软骨-半月板和软骨下骨表型相关，但在 Kellgren-Lawrence 2 期膝关节中发病率较低。核磁共振成像增强了表型特征，有助于在骨关节炎治疗中进行更精确和个性化的管理。尽管与核磁共振成像相比存在局限性，但射线照相术在评估肥大和萎缩表型方面仍然很有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.