Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction Causality Analysis Study.

IF 2 4区 医学 Q3 DERMATOLOGY
Yue Zhao, Furong Guo, Mengyue Guo
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引用次数: 0

Abstract

Background: Observational studies have suggested a correlation between alopecia areata (AA) and thyroid dysfunction (TD). However, the causal relationship between AA and TD remains uncertain. The purpose of this study is to investigate the causal relationship between these two conditions. Understanding the potential causal relationship between AA and TD is valuable for elucidating the pathogenesis of AA and for designing innovative methods to prevent and treat AA and its related complications.

Methods: All data for this two-sample Mendelian randomization (MR) study were sourced from public databases. This study selected hypothyroidism, Hashimoto's thyroiditis, hyperthyroidism, subacute thyroiditis, and Graves' disease as exposure factors, with AA as the outcome variable. Data for hypothyroidism, Hashimoto's thyroiditis, hyperthyroidism, subacute thyroiditis, Graves' disease, and AA were obtained from related genome-wide association studies (GWAS). Various MR analysis methods such as inverse variance weighted (IVW), MR-Egger, and weighted median were utilized. Additionally, Cochrane's Q test was used to detect heterogeneity in MR results, and the MR-Egger intercept test and MR pleiotropy residual sum and outlier (MR-PRESSO) test were used to detect horizontal pleiotropy. A leave-one-out analysis was conducted to investigate the sensitivity of this association.

Results: We found statistically significant genetic predictions of AA with hypothyroidism, Hashimoto's thyroiditis, and subacute thyroiditis (IVW OR = 1.4009815, 95% confidence interval [CI]: 1.1210399-1.750829; p = 0.003030698, OR = 1.396101, 95% CI: 1.030134-1.89208; p = 0.03144273, OR = 0.732702, 95% CI: 0.604812-0.887634; p = 0.001483368). Furthermore, tests for pleiotropy showed no evidence of pleiotropy, enhancing the credibility of the study results. Finally, the leave-one-out test demonstrated the stability and robustness of this association.

Conclusion: This study provides new evidence of a potential genetic link between thyroid issues and AA. By employing the two-sample MR method to eliminate confounding factors and reverse causation, unbiased results were obtained, confirming a causal relationship between hypothyroidism, Hashimoto's thyroiditis, subacute thyroiditis, and AA. This lays the foundation for further mechanistic studies and potential clinical applications. Future research should further explore the specific biological mechanisms between TD and the onset of AA.

甲状腺功能障碍与脱发:遗传预测因果关系分析研究
背景:观察性研究表明,斑秃(AA)与甲状腺功能障碍(TD)之间存在相关性。然而,AA 和 TD 之间的因果关系仍不确定。本研究旨在调查这两种疾病之间的因果关系。了解AA和TD之间的潜在因果关系对于阐明AA的发病机制以及设计预防和治疗AA及其相关并发症的创新方法非常有价值:这项双样本孟德尔随机化(MR)研究的所有数据均来自公共数据库。本研究选择甲状腺功能减退症、桥本氏甲状腺炎、甲状腺功能亢进症、亚急性甲状腺炎和巴塞杜氏病作为暴露因素,AA作为结果变量。甲状腺功能减退症、桥本氏甲状腺炎、甲状腺功能亢进症、亚急性甲状腺炎、巴塞杜氏病和 AA 的数据来自相关的全基因组关联研究(GWAS)。采用了多种 MR 分析方法,如反方差加权(IVW)、MR-Egger 和加权中位数。此外,还使用 Cochrane's Q 检验来检测 MR 结果的异质性,并使用 MR-Egger 截距检验和 MR pleiotropy residual sum and outlier(MR-PRESSO)检验来检测水平褶状效应。为了研究这种关联的敏感性,我们进行了撇除分析:结果:我们发现 AA 与甲状腺功能减退症、桥本氏甲状腺炎和亚急性甲状腺炎的遗传预测具有统计学意义(IVW OR = 1.4009815,95% 置信区间 [CI]:1.1210399-1.1210399):P=0.003030698,OR=1.396101,95% CI:1.030134-1.89208;P=0.03144273,OR=0.732702,95% CI:0.604812-0.887634;P=0.001483368)。此外,多效性测试表明没有多效性的证据,从而提高了研究结果的可信度。最后,leave-one-out 检验证明了这种关联的稳定性和稳健性:本研究为甲状腺问题与 AA 之间的潜在遗传联系提供了新证据。通过采用双样本 MR 法消除混杂因素和反向因果关系,获得了无偏见的结果,证实了甲状腺功能减退症、桥本氏甲状腺炎、亚急性甲状腺炎和 AA 之间的因果关系。这为进一步的机理研究和潜在的临床应用奠定了基础。未来的研究应进一步探讨 TD 与 AA 发病之间的具体生物机制。
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来源期刊
Skin Research and Technology
Skin Research and Technology 医学-皮肤病学
CiteScore
3.30
自引率
9.10%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
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