The effect of ceramides on skin absorption by Raman spectroscopy.

IF 2 4区医学 Q3 DERMATOLOGY

Skin Research and Technology Pub Date : 2024-10-01 DOI:10.1111/srt.70046

Song Hee Kim, Jeonghoon Yun, Woncheol Kim, Eunsu Seon, Chanhwi Lee, Jaejoon Jeon, Mid Eum Yun, Keun Hyung Park

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引用次数: 0

Abstract

Introduction: Ceramides are essential epidermal constituents that play a critical role in skin moisturization treatment as a raw material in cosmetics formulation. Recently, ceramides have been known to be frequently applied in various cosmetic formulations. Despite ceramide's beneficial characteristics, academic research regarding ceramides and their skin absorption remains insufficient. Therefore, our study conducted clinical research employing Raman spectroscopy to investigate the effects of ceramides on skin absorption to enhance the understanding of ceramides' dermatological functionality and their topical application in cosmetics science.

Materials and methods: Twenty healthy individuals with dry skin have participated in this clinical trial. In this double-arm designed trial, the test group received an investigational product with ceramides (5000 ppm) and a control group received an investigational product without the ceramides while all other components remained identical. The subjects visited the clinical research center and acclimatized for 30 min in constant humidity and temperature for equilibrium, subsequently conducting a measurement. Before the trial, the research subject's target site (lower arm area) was kept clean, devoid of any cosmetic administering 24 h before the trial when investigational product was topically applied.

Results: Our findings with Raman spectroscopy statistically demonstrate that skin absorption amount, speed and depth for both groups improved overall (p < 0.05) after administration of the investigational product. Notably, the test group received an investigational product with ceramides (5000 ppm) indicating superior effectiveness across all parameters compared to a control group from comparison analysis of each parameter (p < 0.05).

Conclusion: This study concludes that ceramide-containing cosmetics provide a beneficial effect on skin absorption via visual and statistical results of Raman spectroscopy analysis.

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通过拉曼光谱分析神经酰胺对皮肤吸收的影响。

介绍：神经酰胺是表皮的重要成分，作为化妆品配方的原料，在皮肤保湿护理中发挥着关键作用。近来，神经酰胺已被广泛应用于各种化妆品配方中。尽管神经酰胺具有有益的特性，但有关神经酰胺及其皮肤吸收的学术研究仍然不足。因此，我们的研究采用拉曼光谱进行临床研究，探讨神经酰胺对皮肤吸收的影响，以加深对神经酰胺的皮肤学功能及其在化妆品科学中的局部应用的了解：20 名健康的干性皮肤患者参与了这项临床试验。在这项双臂设计的试验中，试验组接受含有神经酰胺（5000 ppm）的研究产品，对照组接受不含神经酰胺的研究产品，其他成分保持不变。受试者前往临床研究中心，在恒定的湿度和温度下适应 30 分钟以达到平衡，随后进行测量。试验前，研究对象的目标部位（下臂区域）保持清洁，试验前 24 小时不使用任何化妆品，同时局部涂抹研究产品：结果：拉曼光谱的统计结果表明，两组研究对象的皮肤吸收量、吸收速度和吸收深度均有整体改善（p 结论：本研究得出结论，使用陶瓷酰胺的研究对象的皮肤吸收量、吸收速度和吸收深度均有整体改善：本研究通过拉曼光谱分析的直观和统计结果得出结论，含神经酰胺的化妆品对皮肤吸收有好处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.