m6A modification of RNA in cervical cancer: role and clinical perspectives.

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
RNA Biology Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI:10.1080/15476286.2024.2408707
Yajuan Gao, Qi Guo, Liming Yu
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引用次数: 0

Abstract

N6-methyladenosine (m6A) is widely recognized as the predominant form of RNA modification in higher organisms, with the capability to finely regulate RNA metabolism, thereby influencing a series of crucial physiological and pathological processes. These processes include regulation of gene expression, cell proliferation, invasion and metastasis, cell cycle control, programmed cell death, interactions within the tumour microenvironment, energy metabolism, and immune regulation. With advancing research into the mechanisms of RNA methylation, the pivotal role of m6A modification in the pathophysiology of reproductive system tumours, particularly cervical cancer, has been progressively unveiled. This discovery has opened new research avenues and presented significant potential for the diagnosis, prognostic evaluation, and treatment of diseases. This review delves deeply into the biological functions of m6A modification and its mechanisms of action in the onset and progression of cervical cancer. Furthermore, it explores the prospects of m6A modification in the precision diagnosis and treatment of cervical cancer, aiming to provide new perspectives and a theoretical basis for innovative and advanced treatment strategies for cervical cancer.

宫颈癌中 RNA 的 m6A 修饰:作用和临床前景。
人们普遍认为,N6-甲基腺苷(m6A)是高等生物体内主要的 RNA 修饰形式,能够精细调节 RNA 代谢,从而影响一系列关键的生理和病理过程。这些过程包括基因表达调控、细胞增殖、侵袭和转移、细胞周期控制、细胞程序性死亡、肿瘤微环境中的相互作用、能量代谢和免疫调节。随着对 RNA 甲基化机制研究的不断深入,m6A 修饰在生殖系统肿瘤(尤其是宫颈癌)病理生理学中的关键作用已逐渐被揭示出来。这一发现开辟了新的研究途径,为疾病的诊断、预后评估和治疗提供了巨大的潜力。本综述深入探讨了 m6A 修饰的生物学功能及其在宫颈癌发病和进展过程中的作用机制。此外,它还探讨了 m6A 修饰在宫颈癌精准诊断和治疗中的应用前景,旨在为宫颈癌的创新和先进治疗策略提供新的视角和理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
RNA Biology
RNA Biology 生物-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
82
审稿时长
1 months
期刊介绍: RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy
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