Wild sympatric rodents inhabiting pig farm environments may facilitate the spillover of Enterocytozoon bieneusi from pig farms.

IF 2.3 2区医学 Q2 PARASITOLOGY

Parasite Pub Date : 2024-01-01 Epub Date: 2024-09-27 DOI:10.1051/parasite/2024061

Fa Shan, Qingda Meng, Fang Wang, Jinfeng Zhao, Huiyan Xu, Nanhao Wang, Yufeng Liu, Sumei Zhang, Guanghui Zhao, Longxian Zhang

{"title":"Wild sympatric rodents inhabiting pig farm environments may facilitate the spillover of Enterocytozoon bieneusi from pig farms.","authors":"Fa Shan, Qingda Meng, Fang Wang, Jinfeng Zhao, Huiyan Xu, Nanhao Wang, Yufeng Liu, Sumei Zhang, Guanghui Zhao, Longxian Zhang","doi":"10.1051/parasite/2024061","DOIUrl":null,"url":null,"abstract":"<p><p>Enterocytozoon bieneusi is a zoonotic pathogen prevalent in mammalian and avian hosts across the globe. Wild small mammals, being abundant worldwide, serve as important sources of zoonotic disease transmission to humans. Here, 227 fecal samples were collected from five rodent and shrew species on 34 pig farms in China to investigate the prevalence and molecular characterization of E. bieneusi. The overall prevalence of E. bieneusi was 17.18% (39/227), with a distribution of 23.53% (32/136) in Rattus tanezumi, 8.62% (5/58) in Rattus norvegicus, and 8.00% (2/25) in Mus musculus. Eight E. bieneusi genotypes were identified, comprising four known genotypes: D (n = 8), EbpC (n = 8), PigEBITS7 (n = 9), and EbpA (n = 2), and four novel genotypes: CHPR1 (n = 7), CHPR2 (n = 1), CHPR3 (n = 2), and CHPR4 (n = 2). This study is the first to report E. bieneusi in rodents from pig farms in Henan, Shaanxi, and Shanxi Provinces in China. The host range of genotype EbpC was expanded with its first detection in M. musculus and R. tanezumi. All identified E. bieneusi genotypes belong to group 1, raising concerns about these sympatric rodents being reservoirs of zoonotic transmission. Moreover, the widespread distribution of genotype EbpC suggests potential cross-species transmission between sympatric rodents and domestic pigs. Our findings highlight the potential role of sympatric rodents in facilitating the spillover of E. bieneusi from pig farms, which could pose a potential public health threat.</p>","PeriodicalId":19796,"journal":{"name":"Parasite","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11433834/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasite","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1051/parasite/2024061","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Enterocytozoon bieneusi is a zoonotic pathogen prevalent in mammalian and avian hosts across the globe. Wild small mammals, being abundant worldwide, serve as important sources of zoonotic disease transmission to humans. Here, 227 fecal samples were collected from five rodent and shrew species on 34 pig farms in China to investigate the prevalence and molecular characterization of E. bieneusi. The overall prevalence of E. bieneusi was 17.18% (39/227), with a distribution of 23.53% (32/136) in Rattus tanezumi, 8.62% (5/58) in Rattus norvegicus, and 8.00% (2/25) in Mus musculus. Eight E. bieneusi genotypes were identified, comprising four known genotypes: D (n = 8), EbpC (n = 8), PigEBITS7 (n = 9), and EbpA (n = 2), and four novel genotypes: CHPR1 (n = 7), CHPR2 (n = 1), CHPR3 (n = 2), and CHPR4 (n = 2). This study is the first to report E. bieneusi in rodents from pig farms in Henan, Shaanxi, and Shanxi Provinces in China. The host range of genotype EbpC was expanded with its first detection in M. musculus and R. tanezumi. All identified E. bieneusi genotypes belong to group 1, raising concerns about these sympatric rodents being reservoirs of zoonotic transmission. Moreover, the widespread distribution of genotype EbpC suggests potential cross-species transmission between sympatric rodents and domestic pigs. Our findings highlight the potential role of sympatric rodents in facilitating the spillover of E. bieneusi from pig farms, which could pose a potential public health threat.

查看原文本刊更多论文

栖息在养猪场环境中的野生同域啮齿类动物可能会促进猪场中的生物肠虫外溢。

生物肠杆菌（Enterocytozoon bieneusi）是一种流行于全球哺乳动物和鸟类宿主的人畜共患病原体。野生小型哺乳动物遍布全球，是人畜共患病传播给人类的重要来源。本文收集了中国 34 个养猪场中 5 种啮齿类动物和鼩鼱类动物的 227 份粪便样本，以研究 E. bieneusi 的流行情况和分子特征。E.bieneusi的总体流行率为17.18%（39/227），在Rattus tanezumi中的分布率为23.53%（32/136），在Rattus norvegicus中的分布率为8.62%（5/58），在Mus musculus中的分布率为8.00%（2/25）。确定了 8 个 E. bieneusi 基因型，包括 4 个已知基因型：D（n = 8）、EbpC（n = 8）、PigEBITS7（n = 9）和 EbpA（n = 2），以及四种新型基因型：CHPR1（n = 7）、CHPR2（n = 1）、CHPR3（n = 2）和 CHPR4（n = 2）。本研究首次报道了中国河南省、陕西省和山西省养猪场啮齿动物中的 E. bieneusi。基因型 EbpC 的宿主范围有所扩大，首次在 M. musculus 和 R. tanezumi 中检测到该基因型。所有确定的E. bieneusi基因型都属于第1组，这引起了人们对这些同域啮齿动物成为人畜共患病传播源的担忧。此外，基因型 EbpC 的广泛分布表明，同域啮齿动物与家猪之间可能存在跨物种传播。我们的研究结果凸显了同域啮齿动物在促进猪场E. bieneusi外溢方面的潜在作用，这可能会对公共健康构成潜在威胁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Parasite 医学-寄生虫学

CiteScore

5.50

自引率

6.90%

发文量

审稿时长

3 months

期刊介绍： Parasite is an international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology. Reviews, articles and short notes may be submitted. Fields include, but are not limited to: general, medical and veterinary parasitology; morphology, including ultrastructure; parasite systematics, including entomology, acarology, helminthology and protistology, and molecular analyses; molecular biology and biochemistry; immunology of parasitic diseases; host-parasite relationships; ecology and life history of parasites; epidemiology; therapeutics; new diagnostic tools. All papers in Parasite are published in English. Manuscripts should have a broad interest and must not have been published or submitted elsewhere. No limit is imposed on the length of manuscripts, but they should be concisely written. Papers of limited interest such as case reports, epidemiological studies in punctual areas, isolated new geographical records, and systematic descriptions of single species will generally not be accepted, but might be considered if the authors succeed in demonstrating their interest.