Risk of cardiovascular disease among head and neck cancer survivors: A population-based matched cohort study

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2024-09-29 DOI:10.1016/j.oraloncology.2024.107041

Katherine Keefe , Hilary C. McCrary , Mei Wei , Bayarmaa Mark , Sarah Drejet , Richard B. Cannon , Luke O. Buchmann , Jason P. Hunt , Mark Dodson , Vikrant Deshmukh , Michael Newman , Marcus M. Monroe , Mia Hashibe

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引用次数: 0

Abstract

Background

In the United States, approximately 63,000 Americans develop head and neck cancer (HNC) annually. Our study aims were to investigate cardiovascular complications and risk factors for development of CVD among HNC survivors.

Methods

Utilizing the Utah Populations Database, a total of 1,901 HNC patients diagnosed and 7,796 birth year, sex, and birth state matched individuals from the general population were identified. Multivariate Cox proportional hazard models were used.

Results

Within the first two years after cancer diagnosis, HNC survivors had a higher likelihood of developing cardiovascular disease (CVD). High Charleston Comorbidity Index (CCI) score at baseline (Hazard Ratio (HR) 1.67, 95 % 1.28–2.17), stage II and IV disease (HR 1.80, 95 % 1.29–2.51), age >=65 years old (HR 2.31, 95 % 1.85–2.88), chemotherapy (HR 1.47, 95 % 1.15–1.88) were associated with increased CVD risk.

Conclusions

Compared to the general population, HNC survivors were more likely to develop cardiovascular diseases, particularly if they had the following risk factors: older age, stage II or IV cancer, high baseline CCI score, and chemotherapy were risk factors for development of CVD.

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头颈癌幸存者罹患心血管疾病的风险：基于人群的匹配队列研究

背景：在美国，每年约有 63,000 名美国人罹患头颈癌 (HNC)。我们的研究目的是调查 HNC 幸存者的心血管并发症和心血管疾病的风险因素：利用犹他州人口数据库，共确定了 1,901 名确诊的 HNC 患者和 7,796 名与出生年份、性别和出生州相匹配的普通人群。研究采用了多变量考克斯比例危险模型：结果：在癌症确诊后的头两年内，HNC 幸存者患心血管疾病（CVD）的可能性较高。基线查尔斯顿合并症指数（CCI）得分高（危险比（HR）1.67，95 % 1.28-2.17）、疾病处于II期和IV期（HR 1.80，95 % 1.29-2.51）、年龄>=65岁（HR 2.31，95 % 1.85-2.88）、化疗（HR 1.47，95 % 1.15-1.88）与心血管疾病风险增加有关：结论：与普通人群相比，HNC幸存者更容易罹患心血管疾病，尤其是当他们具有以下风险因素时：高龄、II期或IV期癌症、高基线CCI评分和化疗是罹患心血管疾病的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.