Task-based modulation of functional connectivity of dorsal attention network in adult-ADHD

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2024-09-27 DOI:10.1016/j.neulet.2024.137998

Baris Metin , Secil Damla Kayaalp , Shams Farhad , Elvan Ciftci , Buse Gocmen Er , Nevzat Tarhan

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引用次数: 0

Abstract

Recent studies have prompted a shift in the understanding of attention deficit hyperactivity disorder (ADHD) from models positing dysfunction of individual brain areas to those that assume alterations in large-scale brain networks. Despite this shift, the underlying neural mechanism of ADHD in the adult population remains uncertain. With functional magnetic resonance imaging (fMRI), this study examined brain connectivity of dorsal and ventral attention networks. Adults with and without ADHD completed a Go/No-Go task inside the scanner and the functional connectivity of attention networks was analysed. The generalized psychophysiological interaction analysis indicated differences involving the dorsal attention network. For the ADHD group, an interaction effect revealed altered dorsal attention-default mode network connectivity modulation, particularly between the right frontal eye field and posterior cingulate gyrus. We conclude that dorsal attention network dysfunction may be involved in sustained attention deficits in adult-ADHD. This study sheds light into network-level alterations contributing to the understanding of adult-ADHD, which may be a potential avenue for future research and clinical interventions.

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基于任务的成人多动症背侧注意网络功能连接调制。

最近的研究促使人们对注意力缺陷多动障碍（ADHD）的认识从假设单个脑区功能障碍的模型转向假设大规模脑网络发生改变的模型。尽管发生了这种转变，但成人多动症的潜在神经机制仍不确定。本研究通过功能磁共振成像（fMRI）检查了背侧和腹侧注意力网络的大脑连接性。患有和未患有多动症的成年人在扫描仪内完成了一项 Go/No-Go 任务，并对注意力网络的功能连接进行了分析。广义心理生理学交互作用分析表明，背侧注意力网络存在差异。对于注意力缺陷障碍组，交互作用效应显示了背侧注意力-默认模式网络连接调制的改变，尤其是在右侧额叶眼区和扣带回后部之间。我们的结论是，背侧注意力网络功能障碍可能与成人多动症的持续注意力缺陷有关。这项研究揭示了网络层面的改变，有助于理解成人多动症，这可能是未来研究和临床干预的潜在途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

期刊介绍： Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.