Rosmarinus officinalis and Zataria multiflora extracts enhanced antibacterial activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-10-01 DOI:10.1080/14786419.2024.2409982

Zahra Samadi, Seyed Sadeq Mousavi Ghahfarrokhi, Hossein Jafari, Sepideh Nikrou, Mahdi Vazirian, Nasrin Samadi

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Abstract

The study investigates the antibacterial potential of hydroalcoholic extracts from Rosmarinus officinalis and Zataria multiflora, combined with ciprofloxacin, against methicillin-resistant Staphylococcus aureus (MRSA). Initial screening showed promising results, leading to further exploration of the synergistic effect of the extracts and ciprofloxacin. The combination of the two extracts had an additive effect, while the combination of each extract with ciprofloxacin resulted in partial synergism. The most significant synergistic effect was observed against MRSA 9, with a 3200-fold reduction in the MIC value of ciprofloxacin. The similar inhibitory concentration of the extracts for all MRSA strains suggests these non-antibiotic agents have a broad spectrum of activity against MRSA. This offers a promising avenue for developing new therapeutic approaches to tackle drug-resistant bacterial infections. The results highlight the potential of combining R. officinalis and Z. multiflora extracts with ciprofloxacin to enhance antibacterial efficacy against MRSA strains.

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迷迭香和万年青提取物增强了环丙沙星对耐甲氧西林金黄色葡萄球菌的抗菌活性。

本研究探讨了迷迭香和多花月见草的水醇提取物与环丙沙星结合对耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌潜力。初步筛选显示出良好的结果，从而进一步探索了提取物与环丙沙星的协同作用。两种提取物的组合具有相加效应，而每种提取物与环丙沙星的组合则产生部分协同效应。对 MRSA 9 的协同作用最为明显，环丙沙星的 MIC 值降低了 3200 倍。提取物对所有 MRSA 菌株的抑制浓度相似，这表明这些非抗生素制剂对 MRSA 具有广谱的活性。这为开发新的治疗方法以应对耐药细菌感染提供了一个前景广阔的途径。研究结果凸显了将R. officinalis和Z. multiflora提取物与环丙沙星结合使用以增强对MRSA菌株的抗菌效果的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.