Associations of Intermittent Hypoxia Burden with Gut Microbiota Dysbiosis in Adult Patients with Obstructive Sleep Apnea.

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S484377

Wenbin Guo, Lin Sun, Huijun Yue, Xueqin Guo, Lin Chen, Jinhong Zhang, Zhuqi Chen, Yiming Wang, Jiao Wang, Wenbin Lei

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Abstract

Purpose: Clinical studies focusing on the association between the gut microbiota and obstructive sleep apnea (OSA) are limited. This study aimed to explore the relationship between intermittent hypoxia and the composition of gut microbiota in adults by analyzing the differences in the characteristics and functional distribution of gut microbiota between patients with different severities of OSA and healthy individuals.

Patients and methods: A cohort of 113 individuals from the First Affiliated Hospital of Sun Yat-sen University underwent overnight polysomnography from July 2019 to August 2021. The individuals included 16 healthy controls and 97 patients with OSA, categorized by the apnea-hypopnea index into mild, moderate, and severe groups. Fecal samples were analyzed using high-throughput sequencing of the 16S rRNA V3-V4 region to assess gut microbiota composition and function. Correlation analysis was used to evaluate the association between clinical indicators and microbiota markers.

Results: In patients with OSA, the gut microbiota diversity and the abundance of specific microbes that produce short-chain fatty acids decreased (P<0.05). The phyla Verrucomicrobia and Candidatus Saccharibacteria, genera Gemmiger and Faecalibacterium, and the species Gemmiger formicilis exhibited decreasing abundance with increasing OSA severity. Correlation analysis revealed a robust association between the proportion of total sleep time, characterized by nighttime blood oxygen saturation below 90%, and the alterations in the gut microbiota, demonstrating that elevated levels of desaturation are correlated with pronounced microbiota dysbiosis (P<0.05).

Conclusion: Compared to the control group, the intermittent hypoxia exhibited by patients with OSA may be related to alterations in the composition and structure of the gut microbiota. Our results demonstrate the importance of monitoring hypoxia indicators in future clinical practice.

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阻塞性睡眠呼吸暂停成人患者间歇性缺氧负担与肠道微生物群失调的关系

目的：有关肠道微生物群与阻塞性睡眠呼吸暂停（OSA）之间关系的临床研究十分有限。本研究旨在通过分析不同严重程度的 OSA 患者与健康人之间肠道微生物群的特征和功能分布差异，探讨间歇性缺氧与成人肠道微生物群组成之间的关系：中山大学附属第一医院的113名患者在2019年7月至2021年8月期间接受了夜间多导睡眠图检查。其中包括 16 名健康对照者和 97 名 OSA 患者，按呼吸暂停-低通气指数分为轻度、中度和重度组。采用 16S rRNA V3-V4 区域高通量测序分析粪便样本，以评估肠道微生物群的组成和功能。相关分析用于评估临床指标与微生物群标记之间的关联：结果：在 OSA 患者中，肠道微生物群的多样性和产生短链脂肪酸的特定微生物的丰度均有所下降（PC结论：与对照组相比，OSA 患者的肠道微生物群的多样性和产生短链脂肪酸的特定微生物的丰度均有所下降：与对照组相比，OSA 患者表现出的间歇性缺氧可能与肠道微生物群的组成和结构改变有关。我们的研究结果表明了在未来临床实践中监测缺氧指标的重要性。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.