Serum creatinine is more strongly associated with hyperuricemia than eGFR in males but not in females.

IF 1.8 4区 医学 Q3 RHEUMATOLOGY
Yukana Chihara, Ichiro Wakabayashi, Yuki Kataoka, Tetsuya Yamamoto
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引用次数: 0

Abstract

Objectives: Serum creatinine and estimated glomerular filtration ratio (eGFR) are factors associated with hyperuricemia, though which is more closely associated with hyperuricemia remains unclear.

Subjects and methods: This retrospective cross-sectional study examined the associations of serum creatinine and eGFR with hyperuricemia using health check-up findings. Enrolled were 6020 individuals (3509 males, 2511 females) who underwent health check-ups from 2017 to 2021. The subjects were divided based on serum uric acid level into the normuricemia (males 1.5-7.0 mg/dl, females 1.5-< 6.0 mg/dl) and hyperuricemia (males >7.0 mg/dl, female ≥ 6.0 mg/dl) groups. Matched-pair analysis was used to evaluate the association between hyperuricemia and variables related to serum uric acid.

Results: Matched-pair analysis results showed a significant association of serum creatinine with hyperuricemia in male subjects but not in females. Furthermore, propensity score obtained by binominal logistic regression demonstrated that serum creatinine had a greater association with hyperuricemia than eGFR in the males but not in females.

Conclusions: The present findings indicate an association of serum creatinine with hyperuricemia in males not only because of reduced renal function but other factors related to greater muscle mass, such as increased intake of protein-rich foods containing purines and increased uric acid production induced by accelerated creatinine metabolism.

在男性中,血清肌酐与高尿酸血症的关系比肾小球滤过率与高尿酸血症的关系更密切,而在女性中则不然。
目标:血清肌酐和估计肾小球滤过率(eGFR)是与高尿酸血症相关的因素,但哪一个与高尿酸血症的关系更密切仍不清楚:这项回顾性横断面研究利用健康体检结果研究了血清肌酐和估计肾小球滤过率与高尿酸血症的关系。研究共纳入 6020 人(男性 3509 人,女性 2511 人),他们在 2017 年至 2021 年期间接受了健康体检。根据血清尿酸水平将受试者分为正常尿酸血症组(男性1.5-7.0 mg/dl,女性1.5-7.0 mg/dl,女性≥6.0 mg/dl)。采用配对分析法评估高尿酸血症与血清尿酸相关变量之间的关系:结果:配对分析结果显示,男性受试者的血清肌酐与高尿酸血症有显著关联,而女性受试者则没有。此外,通过二项式逻辑回归得出的倾向得分显示,男性血清肌酐与高尿酸血症的关系大于 eGFR,而女性则不然:本研究结果表明,男性血清肌酐与高尿酸血症之间存在关联,这不仅是由于肾功能减退,还与肌肉质量增加有关,如摄入含有嘌呤的富含蛋白质的食物增加,以及肌酐代谢加速导致尿酸生成增加等其他因素有关。
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来源期刊
Modern Rheumatology
Modern Rheumatology RHEUMATOLOGY-
CiteScore
4.90
自引率
9.10%
发文量
146
审稿时长
1.5 months
期刊介绍: Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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